Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Discordance between Prevalent Vertebral Fracture and Vertebral Strength Estimated by the Finite Element Method Based on Quantitative Computed Tomography in Patients with Type 2 Diabetes Mellitus.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Kiyohara N;Kiyohara N; Yamamoto M; Yamamoto M; Sugimoto T; Sugimoto T
  • المصدر:
    PloS one [PLoS One] 2015 Dec 07; Vol. 10 (12), pp. e0144496. Date of Electronic Publication: 2015 Dec 07 (Print Publication: 2015).
  • نوع النشر :
    Journal Article; Observational Study; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science
    • الموضوع:
      Finite Element Analysis*; Diabetes Mellitus, Type 2/*physiopathology ; Lumbar Vertebrae/*diagnostic imaging ; Spinal Fractures/*epidemiology ; Tomography, X-Ray Computed/*methods; Aged ; Aged, 80 and over ; Bone Density ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnostic imaging ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Regression Analysis ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/etiology
    • نبذة مختصرة :
      Background: Bone fragility is increased in patients with type 2 diabetes mellitus (T2DM), but a useful method to estimate bone fragility in T2DM patients is lacking because bone mineral density alone is not sufficient to assess the risk of fracture. This study investigated the association between prevalent vertebral fractures (VFs) and the vertebral strength index estimated by the quantitative computed tomography-based nonlinear finite element method (QCT-based nonlinear FEM) using multi-detector computed tomography (MDCT) for clinical practice use.
      Research Design and Methods: A cross-sectional observational study was conducted on 54 postmenopausal women and 92 men over 50 years of age, all of whom had T2DM. The vertebral strength index was compared in patients with and without VFs confirmed by spinal radiographs. A standard FEM procedure was performed with the application of known parameters for the bone material properties obtained from nondiabetic subjects.
      Results: A total of 20 women (37.0%) and 39 men (42.4%) with VFs were identified. The vertebral strength index was significantly higher in the men than in the women (P<0.01). Multiple regression analysis demonstrated that the vertebral strength index was significantly and positively correlated with the spinal bone mineral density (BMD) and inversely associated with age in both genders. There were no significant differences in the parameters, including the vertebral strength index, between patients with and without VFs. Logistic regression analysis adjusted for age, spine BMD, BMI, HbA1c, and duration of T2DM did not indicate a significant relationship between the vertebral strength index and the presence of VFs.
      Conclusion: The vertebral strength index calculated by QCT-based nonlinear FEM using material property parameters obtained from nondiabetic subjects, whose risk of fracture is lower than that of T2DM patients, was not significantly associated with bone fragility in patients with T2DM. This discordance may indirectly suggest that patients with T2DM have deteriorated bone material compared with nondiabetic subjects, a potential cause of bone fragility in T2DM patients.
    • References:
      JAMA. 2001 Feb 14;285(6):785-95. (PMID: 11176917)
      J Bone Miner Res. 2014 Apr;29(4):787-95. (PMID: 24123088)
      J Bone Miner Res. 1993 Sep;8(9):1137-48. (PMID: 8237484)
      J Biomech. 1998 Feb;31(2):125-33. (PMID: 9593205)
      Biomed Tech (Berl). 1998 Apr;43(4):82-8. (PMID: 9611393)
      J Orthop Res. 1998 May;16(3):300-8. (PMID: 9671924)
      Spine (Phila Pa 1976). 2006 Jul 15;31(16):1789-94. (PMID: 16845352)
      Osteoporos Int. 2006 Oct;17(10):1514-23. (PMID: 16770520)
      Bone. 2007 Mar;40(3):767-74. (PMID: 17174619)
      Osteoporos Int. 2007 Apr;18(4):427-44. (PMID: 17068657)
      Am J Epidemiol. 2007 Sep 1;166(5):495-505. (PMID: 17575306)
      J Clin Endocrinol Metab. 2008 Mar;93(3):1013-9. (PMID: 18160470)
      J Bone Miner Res. 2009 Apr;24(4):702-9. (PMID: 19049338)
      Osteoporos Int. 2009 May;20(5):801-10. (PMID: 18800178)
      JAMA. 2011 Jun 1;305(21):2184-92. (PMID: 21632482)
      Osteoporos Int. 2012 Feb;23(2):563-72. (PMID: 21344244)
      J Bone Miner Res. 2012 Apr;27(4):808-16. (PMID: 22190331)
      Bone. 2003 Oct;33(4):744-50. (PMID: 14555280)
    • الموضوع:
      Date Created: 20151208 Date Completed: 20160628 Latest Revision: 20181113
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC4671717
    • الرقم المعرف:
      10.1371/journal.pone.0144496
    • الرقم المعرف:
      26642210