Frequencies of the Arg16Gly, Gln27Glu and Thr164Ile Adrenoceptor β2 Polymorphisms among Omanis.

Publisher: Sultan Qaboos University Country of Publication: Oman NLM ID: 101519915 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2075-051X (Print) Linking ISSN: 2075051X NLM ISO Abbreviation: Sultan Qaboos Univ Med J Subsets: PubMed not MEDLINE

Original Publication: Muscat : Sultan Qaboos University

Objectives: This study aimed to assess the distribution of missense mutations in the adrenoceptor β2 (ADRB2) gene in an Omani cohort.
Methods: This study was carried out between May 2014 and March 2015 at the Sultan Qaboos University, Muscat, Oman. Blood samples were taken from 316 unrelated Omani subjects. Genotyping for rs1042713 (c.46A>G, p.Arg16Gly), rs1042714 (c.79C>G, p.Gln27Glu) and rs1800888 (c.491C>T, p.Thr164Ile) polymorphisms was performed by real-time polymerase chain reaction using single nucleotide polymorphism (SNP) genotyping assays. The allelic frequencies of these polymorphisms were estimated on the basis of the observed numbers of specific alleles from the genotype data for male and female subjects. The genotype frequencies for each polymorphism were tested for deviation from the Hardy-Weinberg equilibrium.
Results: Gly16 and Glu27 were the most frequent variants found among the cohort (63% and 75%, respectively). The Ile164 variant was not detected in the study population. There was a significant linkage disequilibrium between the rs1042713 and rs1042714 SNPs (r(2) = 0.209; P ≤0.001). The most observed haplotypes were Gly16-Gln27 and Arg16-Gln27 (0.37 and 0.38, respectively). The frequency of Gly16-Glu27 was 0.25, comprising all Glu27 carriers.
Conclusion: The allelic distribution of variants in this Omani cohort was similar to distributions reported among Caucasian populations.

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Keywords: Allele Frequencies; Genetic Polymorphisms; Genotype; Oman; Single Nucleotide Polymorphisms; beta-2 Adrenergic Receptor

Date Created: 20151203 Date Completed: 20151202 Latest Revision: 20220331

20221213

PMC4664092

10.18295/squmj.2015.15.04.007

26629374