Selective sweeps versus introgression - population genetic dynamics of the murine leukemia virus receptor Xpr1 in wild populations of the house mouse (Mus musculus).

Publisher: BioMed Central Country of Publication: England NLM ID: 100966975 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2148 (Electronic) Linking ISSN: 14712148 NLM ISO Abbreviation: BMC Evol Biol Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

Evolution, Molecular*; Leukemia Virus, Murine/*physiology ; Mice/*genetics ; Receptors, G-Protein-Coupled/*genetics ; Receptors, Virus/*genetics; Amino Acid Sequence ; Animals ; Asia, Western ; Base Sequence ; Crosses, Genetic ; Europe ; Female ; Genetics, Population ; Haplotypes ; Host-Pathogen Interactions ; Male ; Mice/classification ; Molecular Sequence Data ; Population Dynamics ; Sequence Alignment ; Xenotropic and Polytropic Retrovirus Receptor

Background: The interaction between viruses and their receptors in the host can be expected to lead to an evolutionary arms race resulting in cycles of rapid adaptations. We focus here on the receptor gene Xpr1 (xenotropic and polytropic retrovirus receptor 1) for murine leukemia viruses (MLVs). In a previous screen for selective sweeps in mouse populations we discovered that a population from Germany was almost monomorphic for Xpr1 haplotypes, while a population from France was polymorphic.
Results: Here we analyze Xpr1 sequences and haplotypes from a broad sample of wild mouse populations of two subspecies, M. m. domesticus and M. m. musculus, to trace the origins of this distinctive polymorphism pattern. We show that the high polymorphism in the population in France is caused by a relatively recent invasion of a haplotype from a population in Iran, rather than a selective sweep in Germany. The invading haplotype codes for a novel receptor variant, which has itself undergone a recent selective sweep in the Iranian population.
Conclusions: Our data support a scenario in which Xpr1 is frequently subject to positive selection, possibly as a response to resistance development against recurrently emerging infectious viruses. During such an infection cycle, receptor variants that may convey viral resistance can be captured from another population and quickly introgress into populations actively dealing with the infectious virus.

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T32 GM008666 United States GM NIGMS NIH HHS

0 (Receptors, G-Protein-Coupled)
0 (Receptors, Virus)
0 (Xenotropic and Polytropic Retrovirus Receptor)
0 (Xpr1 protein, mouse)

Date Created: 20151112 Date Completed: 20160331 Latest Revision: 20220317

20231215

PMC4641351

10.1186/s12862-015-0528-5

26555287