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Urine fibroblast growth factor 23 levels in hypertensive children and adolescents.
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- معلومة اضافية
- المصدر:
Publisher: Medicinska Naklada Country of Publication: Croatia NLM ID: 9424324 Publication Model: Print Cited Medium: Internet ISSN: 1332-8166 (Electronic) Linking ISSN: 03539504 NLM ISO Abbreviation: Croat Med J Subsets: MEDLINE
- بيانات النشر:
Publication: 2001- : Zagreb : Medicinska Naklada
Original Publication: Zagreb : University of Zagreb Medical School, [1992-
- الموضوع:
- نبذة مختصرة :
Aim: To determine the correlation of urinary fibroblast growth factor 23 (FGF23) excretion with blood pressure and calcium-phosphorus metabolism.
Methods: The study included 42 hypertensive (17 girls) and 46 healthy children and adolescents (17 girls) aged 6-18 years admitted to the Department of Pediatrics and Nephrology, Medical University of Białystok between January 2013 and December 2013. FGF23 in urine was measured using Human Intact FGF-23 ELISA Kit.
Results: Hypertensive participants had significantly higher urine FGF23/creatinine values than the reference group (8.65 vs 5.59 RU/mg creatinine, P=0.007). Urine FGF23/creatinine positively correlated with systolic blood pressure in all participants. In hypertensive patients, urine FGF23/creatinine positively correlated with serum calcium and negatively with serum 25(OH)D, urinary calcium, phosphorus, and magnesium.
Conclusion: This study found that FGF23 may play an important role in the pathogenesis of hypertension in children and adolescents, but our results should be confirmed by further studies.
- References:
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- الرقم المعرف:
0 (Biomarkers)
0 (FGF23 protein, human)
27YLU75U4W (Phosphorus)
62031-54-3 (Fibroblast Growth Factors)
7Q7P4S7RRE (Fibroblast Growth Factor-23)
AYI8EX34EU (Creatinine)
SY7Q814VUP (Calcium)
- الموضوع:
Date Created: 20150901 Date Completed: 20160517 Latest Revision: 20211203
- الموضوع:
20231215
- الرقم المعرف:
PMC4576748
- الرقم المعرف:
10.3325/cmj.2015.56.344
- الرقم المعرف:
26321027
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