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Urine fibroblast growth factor 23 levels in hypertensive children and adolescents.

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  • معلومة اضافية
    • المصدر:
      Publisher: Medicinska Naklada Country of Publication: Croatia NLM ID: 9424324 Publication Model: Print Cited Medium: Internet ISSN: 1332-8166 (Electronic) Linking ISSN: 03539504 NLM ISO Abbreviation: Croat Med J Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2001- : Zagreb : Medicinska Naklada
      Original Publication: Zagreb : University of Zagreb Medical School, [1992-
    • الموضوع:
      Biomarkers/*urine ; Fibroblast Growth Factors/*urine ; Hypertension/*urine; Adolescent ; Blood Pressure/physiology ; Calcium/blood ; Child ; Creatinine/blood ; Female ; Fibroblast Growth Factor-23 ; Humans ; Hypertension/blood ; Male ; Phosphorus/blood
    • نبذة مختصرة :
      Aim: To determine the correlation of urinary fibroblast growth factor 23 (FGF23) excretion with blood pressure and calcium-phosphorus metabolism.
      Methods: The study included 42 hypertensive (17 girls) and 46 healthy children and adolescents (17 girls) aged 6-18 years admitted to the Department of Pediatrics and Nephrology, Medical University of Białystok between January 2013 and December 2013. FGF23 in urine was measured using Human Intact FGF-23 ELISA Kit.
      Results: Hypertensive participants had significantly higher urine FGF23/creatinine values than the reference group (8.65 vs 5.59 RU/mg creatinine, P=0.007). Urine FGF23/creatinine positively correlated with systolic blood pressure in all participants. In hypertensive patients, urine FGF23/creatinine positively correlated with serum calcium and negatively with serum 25(OH)D, urinary calcium, phosphorus, and magnesium.
      Conclusion: This study found that FGF23 may play an important role in the pathogenesis of hypertension in children and adolescents, but our results should be confirmed by further studies.
    • References:
      Am J Hypertens. 2011 Aug;24(8):911-7. (PMID: 21525968)
      Kidney Int. 2005 Mar;67(3):1171-8. (PMID: 15698459)
      J Hypertens. 2008 Jul;26(7):1390-4. (PMID: 18551015)
      Clin J Am Soc Nephrol. 2011 Nov;6(11):2688-95. (PMID: 21903990)
      J Clin Hypertens (Greenwich). 2011 Mar;13(3):170-7. (PMID: 21366848)
      Am J Clin Nutr. 2005 Nov;82(5):972-9. (PMID: 16280427)
      Clin J Am Soc Nephrol. 2012 Jul;7(7):1155-62. (PMID: 22554719)
      Am J Physiol Renal Physiol. 2005 Nov;289(5):F1088-95. (PMID: 15998839)
      Kidney Int. 2010 Oct;78(7):679-85. (PMID: 20613714)
      J Cell Biochem. 2003 Feb 1;88(2):327-31. (PMID: 12520534)
      Am J Clin Nutr. 2009 Jun;89(6):1877-83. (PMID: 19369377)
      J Clin Invest. 2002 Jul;110(2):229-38. (PMID: 12122115)
      J Hypertens. 2002 Oct;20(10):1995-2007. (PMID: 12359978)
      J Clin Endocrinol Metab. 2002 Nov;87(11):4957-60. (PMID: 12414858)
      NDT Plus. 2011 Apr;4(2):83-6. (PMID: 25984118)
      Nephrol Dial Transplant. 2010 Mar;25(3):993-7. (PMID: 20037168)
      PLoS One. 2012;7(9):e44161. (PMID: 22970174)
      J Am Soc Nephrol. 2007 Feb;18(2):613-20. (PMID: 17202417)
      Kidney Int. 2008 Jul;74(2):170-9. (PMID: 18385669)
      Atherosclerosis. 2009 Aug;205(2):385-90. (PMID: 19181315)
      J Hypertens. 2012 Oct;30(10):1942-54. (PMID: 22828086)
      Kidney Int. 2003 Dec;64(6):2272-9. (PMID: 14633152)
      Hypertension. 2006 Feb;47(2):296-308. (PMID: 16434724)
      Hypertension. 2010 Mar;55(3):776-84. (PMID: 20083730)
      J Am Soc Nephrol. 2005 Jul;16(7):2205-15. (PMID: 15917335)
      Nephrol Dial Transplant. 2011 Feb;26(2):584-91. (PMID: 20631407)
      N Engl J Med. 1997 Apr 17;336(16):1117-24. (PMID: 9099655)
      EMBO Mol Med. 2014 Jun;6(6):744-59. (PMID: 24797667)
      Stat Med. 1992 Jul;11(10):1305-19. (PMID: 1518992)
      J Am Soc Nephrol. 2009 Jul;20(7):1504-12. (PMID: 19406976)
      Biochem Biophys Res Commun. 2004 Feb 6;314(2):409-14. (PMID: 14733920)
      Eur J Pediatr. 2011 May;170(5):599-609. (PMID: 20972688)
      Clin J Am Soc Nephrol. 2011 Dec;6(12):2871-8. (PMID: 22034506)
      J Hypertens. 2010 Sep;28(9):1821-8. (PMID: 20613627)
      J Clin Endocrinol Metab. 2006 Aug;91(8):3144-9. (PMID: 16735491)
      Hypertension. 2007 May;49(5):1063-9. (PMID: 17372031)
    • الرقم المعرف:
      0 (Biomarkers)
      0 (FGF23 protein, human)
      27YLU75U4W (Phosphorus)
      62031-54-3 (Fibroblast Growth Factors)
      7Q7P4S7RRE (Fibroblast Growth Factor-23)
      AYI8EX34EU (Creatinine)
      SY7Q814VUP (Calcium)
    • الموضوع:
      Date Created: 20150901 Date Completed: 20160517 Latest Revision: 20211203
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC4576748
    • الرقم المعرف:
      10.3325/cmj.2015.56.344
    • الرقم المعرف:
      26321027