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Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles.
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- معلومة اضافية
- المصدر:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
- بيانات النشر:
Original Publication: London : Nature Publishing Group, copyright 2011-
- الموضوع:
- نبذة مختصرة :
Visualizing the movement of angiocatheters during endovascular interventions is typically accomplished using x-ray fluoroscopy. There are many potential advantages to developing magnetic resonance imaging-based approaches that will allow three-dimensional imaging of the tissue/vasculature interface while monitoring other physiologically-relevant criteria, without exposing the patient or clinician team to ionizing radiation. Here we introduce a proof-of-concept development of a magnetic resonance imaging-guided catheter tracking method that utilizes hyperpolarized silicon particles. The increased signal of the silicon particles is generated via low-temperature, solid-state dynamic nuclear polarization, and the particles retain their enhanced signal for ≥ 40 minutes--allowing imaging experiments over extended time durations. The particles are affixed to the tip of standard medical-grade catheters and are used to track passage under set distal and temporal points in phantoms and live mouse models. With continued development, this method has the potential to supplement x-ray fluoroscopy and other MRI-guided catheter tracking methods as a zero-background, positive contrast agent that does not require ionizing radiation.
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- Grant Information:
R25T CA057730 United States CA NCI NIH HHS; CA016672 United States CA NCI NIH HHS; U54 CA151668 United States CA NCI NIH HHS; U54CA151668-03 United States CA NCI NIH HHS; R21 CA185536 United States CA NCI NIH HHS; P30 CA016672 United States CA NCI NIH HHS; R25 CA057730 United States CA NCI NIH HHS
- الرقم المعرف:
0 (Contrast Media)
Z4152N8IUI (Silicon)
- الموضوع:
Date Created: 20150805 Date Completed: 20160802 Latest Revision: 20231112
- الموضوع:
20231112
- الرقم المعرف:
PMC4523869
- الرقم المعرف:
10.1038/srep12842
- الرقم المعرف:
26239953
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