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Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
    • بيانات النشر:
      Publication: New York Ny : Nature Publishing Company
      Original Publication: New York, NY : Nature Pub. Co., [1995-
    • الموضوع:
    • نبذة مختصرة :
      Repair of injured lungs represents a longstanding therapeutic challenge. We show that human and mouse embryonic lung tissue from the canalicular stage of development (20-22 weeks of gestation for humans, and embryonic day 15-16 (E15-E16) for mouse) are enriched with progenitors residing in distinct niches. On the basis of the marked analogy to progenitor niches in bone marrow (BM), we attempted strategies similar to BM transplantation, employing sublethal radiation to vacate lung progenitor niches and to reduce stem cell competition. Intravenous infusion of a single cell suspension of canalicular lung tissue from GFP-marked mice or human fetal donors into naphthalene-injured and irradiated syngeneic or SCID mice, respectively, induced marked long-term lung chimerism. Donor type structures or 'patches' contained epithelial, mesenchymal and endothelial cells. Transplantation of differentially labeled E16 mouse lung cells indicated that these patches were probably of clonal origin from the donor. Recipients of the single cell suspension transplant exhibited marked improvement in lung compliance and tissue damping reflecting the energy dissipation in the lung tissues. Our study provides proof of concept for lung reconstitution by canalicular-stage human lung cells after preconditioning of the pulmonary niche.
    • Comments:
      Comment in: Nat Med. 2015 Aug;21(8):842-4. (PMID: 26248265)
    • References:
      Development. 2006 Jul;133(13):2455-65. (PMID: 16735479)
      Cell Mol Immunol. 2012 May;9(3):208-14. (PMID: 22327211)
      J Cell Physiol. 2015 Jan;230(1):170-9. (PMID: 24915827)
      Cell. 2011 Oct 28;147(3):539-53. (PMID: 22036563)
      Science. 1992 Feb 28;255(5048):1137-41. (PMID: 1372131)
      Nat Biotechnol. 2012 Sep;30(9):876-82. (PMID: 22922672)
      Mol Ther. 2010 Oct;18(10):1830-6. (PMID: 20647998)
      J Urol. 1988 Jan;139(1):204-10. (PMID: 3275800)
      Am J Respir Cell Mol Biol. 2005 Jul;33(1):32-40. (PMID: 15802552)
      Lab Invest. 2011 Mar;91(3):363-78. (PMID: 21079581)
      Physiol Genomics. 2005 Oct 17;23 (2):172-81. (PMID: 16076931)
      Stem Cells. 2006 Feb;24(2):221-9. (PMID: 16109762)
      Proc Natl Acad Sci U S A. 2009 May 26;106(21):8659-64. (PMID: 19433788)
      Nat Med. 2003 Jan;9(1):53-60. (PMID: 12496960)
      Am J Physiol. 1995 Dec;269(6 Pt 1):L791-9. (PMID: 8572241)
      J Clin Invest. 2011 Jul;121(7):2855-62. (PMID: 21701069)
      Am J Pathol. 2004 Feb;164(2):577-88. (PMID: 14742263)
      Biophys J. 2004 Jun;86(6):3993-4003. (PMID: 15189895)
      Cell. 2005 Jun 17;121(6):823-35. (PMID: 15960971)
      Nature. 2010 Aug 12;466(7308):829-34. (PMID: 20703299)
      Radiat Res. 2015 Jan;183(1):124-32. (PMID: 25564721)
      Am J Respir Crit Care Med. 2005 Oct 1;172(7):854-60. (PMID: 15976374)
      N Engl J Med. 2011 May 12;364(19):1795-806. (PMID: 21561345)
      Am J Respir Crit Care Med. 2013 Jul 15;188(2):123-5. (PMID: 23855686)
      J Clin Invest. 2011 Nov;121(11):4409-19. (PMID: 21985786)
      Proc Am Thorac Soc. 2008 Jul 15;5(5):637-67. (PMID: 18625757)
      Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1414-9. (PMID: 20080639)
      J Clin Invest. 2007 Apr;117(4):989-96. (PMID: 17347686)
      Am J Respir Cell Mol Biol. 2001 Jun;24(6):649-52. (PMID: 11415927)
      Diabetes. 2005 Apr;54(4):1048-55. (PMID: 15793243)
      Diabetes. 2009 Jul;58(7):1585-94. (PMID: 19401429)
      Nat Biotechnol. 2014 Jan;32(1):84-91. (PMID: 24291815)
      Nat Med. 2013 Jan;19(1):35-42. (PMID: 23296015)
      Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2928-33. (PMID: 15710886)
      Stem Cells. 2008 May;26(5):1347-55. (PMID: 18339772)
      Stem Cells. 2009 Mar;27(3):623-33. (PMID: 19074419)
      Am J Respir Cell Mol Biol. 2005 Oct;33(4):328-34. (PMID: 15961722)
      Nat Rev Immunol. 2007 Feb;7(2):118-30. (PMID: 17259968)
      Curr Top Microbiol Immunol. 2008;324:53-76. (PMID: 18481452)
      J Cell Sci. 2012 Feb 15;125(Pt 4):932-42. (PMID: 22421361)
      Science. 2014 Nov 14;346(6211):1258810. (PMID: 25395543)
      Am J Respir Cell Mol Biol. 2001 Jun;24(6):662-70. (PMID: 11415930)
      Transplantation. 2009 Feb 15;87(3):309-16. (PMID: 19202432)
      Nat Med. 2014 Aug;20(8):822-32. (PMID: 25100528)
      Proc Am Thorac Soc. 2011 Jun;8(3):223-72. (PMID: 21653527)
      Am J Pathol. 2000 Jan;156(1):269-78. (PMID: 10623675)
      J Clin Invest. 2009 Feb;119(2):336-48. (PMID: 19164856)
      Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19075-80. (PMID: 17148607)
      Cell. 1990 Feb 23;60(4):585-95. (PMID: 1689217)
      Nat Commun. 2014 May 29;5:3923. (PMID: 24879355)
      Transplantation. 2011 Feb 27;91(4):398-405. (PMID: 21192322)
      Xenotransplantation. 2004 Nov;11(6):525-30. (PMID: 15479462)
      Circulation. 2014 May 27;129(21):2144-57. (PMID: 24710033)
      Nature. 2015 Jan 29;517(7536):621-5. (PMID: 25533958)
      Nature. 2015 Jan 29;517(7536):616-20. (PMID: 25383540)
      PLoS Med. 2006 Jul;3(7):e215. (PMID: 16768546)
      Am J Respir Cell Mol Biol. 2011 Jun;44(6):794-803. (PMID: 20656948)
      Nature. 2014 Mar 13;507(7491):190-4. (PMID: 24499815)
      Cell. 2014 Jan 30;156(3):440-55. (PMID: 24485453)
    • الرقم المعرف:
      G34N38R2N1 (Bromodeoxyuridine)
    • الموضوع:
      Date Created: 20150714 Date Completed: 20151104 Latest Revision: 20181113
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1038/nm.3889
    • الرقم المعرف:
      26168294