Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.

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المؤلفون: Nagle CM;Nagle CM; Dixon SC; Dixon SC; Dixon SC; Jensen A; Jensen A; Kjaer SK; Kjaer SK; Kjaer SK; Modugno F; Modugno F; Modugno F; Modugno F; deFazio A; deFazio A; deFazio A; Fereday S; Fereday S; Hung J; Hung J; Hung J; Johnatty SE; Johnatty SE; Fasching PA; Fasching PA; Fasching PA; Beckmann MW; Beckmann MW; Lambrechts D; Lambrechts D; Lambrechts D; Vergote I; Vergote I; Van Nieuwenhuysen E; Van Nieuwenhuysen E; Lambrechts S; Lambrechts S; Risch HA; Risch HA; Rossing MA; Rossing MA; Doherty JA; Doherty JA; Wicklund KG; Wicklund KG; Chang-Claude J; Chang-Claude J; Goodman MT; Goodman MT; Ness RB; Ness RB; Moysich K; Moysich K; Heitz F; Heitz F; Heitz F; du Bois A; du Bois A; du Bois A; Harter P; Harter P; Harter P; Schwaab I; Schwaab I; Matsuo K; Matsuo K; Hosono S; Hosono S; Goode EL; Goode EL; Vierkant RA; Vierkant RA; Larson MC; Larson MC; Fridley BL; Fridley BL; Høgdall C; Høgdall C; Schildkraut JM; Schildkraut JM; Weber RP; Weber RP; Cramer DW; Cramer DW; Terry KL; Terry KL; Bandera EV; Bandera EV; Paddock L; Paddock L; Rodriguez-Rodriguez L; Rodriguez-Rodriguez L; Wentzensen N; Wentzensen N; Yang HP; Yang HP; Brinton LA; Brinton LA; Lissowska J; Lissowska J; Høgdall E; Høgdall E; Høgdall E; Lundvall L; Lundvall L; Whittemore A; Whittemore A; McGuire V; McGuire V; Sieh W; Sieh W; Rothstein J; Rothstein J; Sutphen R; Sutphen R; Anton-Culver H; Anton-Culver H; Ziogas A; Ziogas A; Pearce CL; Pearce CL; Wu AH; Wu AH; Webb PM; Webb PM; Webb PM
المصدر:
British journal of cancer [Br J Cancer] 2015 Sep 01; Vol. 113 (5), pp. 817-26. Date of Electronic Publication: 2015 Jul 07.
نوع النشر :
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة:
English

معلومة اضافية
- Corporate Authors:
  Australian Ovarian Cancer Study Group; Ovarian Cancer Association Consortium
- المصدر:
  Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
- بيانات النشر:
  Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK
  Original Publication: London, Lewis.
- الموضوع:
  Neoplasms, Glandular and Epithelial/*pathology ; Obesity/*pathology ; Ovarian Neoplasms/*pathology; Body Mass Index ; Carcinoma, Ovarian Epithelial ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Neoplasms, Glandular and Epithelial/mortality ; Obesity/mortality ; Ovarian Neoplasms/mortality
- نبذة مختصرة :
  Background: Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. We undertook an international collaborative analysis to assess the association between body mass index (BMI), assessed shortly before diagnosis, progression-free survival (PFS), ovarian cancer-specific survival and overall survival (OS) among women with invasive ovarian cancer.
  Methods: We used original data from 21 studies, which included 12 390 women with ovarian carcinoma. We combined study-specific adjusted hazard ratios (HRs) using random-effects models to estimate pooled HRs (pHR). We further explored associations by histologic subtype.
  Results: Overall, 6715 (54%) deaths occurred during follow-up. A significant OS disadvantage was observed for women who were obese (BMI: 30-34.9, pHR: 1.10 (95% confidence intervals (CIs): 0.99-1.23); BMI: ⩾35, pHR: 1.12 (95% CI: 1.01-1.25)). Results were similar for PFS and ovarian cancer-specific survival. In analyses stratified by histologic subtype, associations were strongest for women with low-grade serous (pHR: 1.12 per 5 kg m(-2)) and endometrioid subtypes (pHR: 1.08 per 5 kg m(-2)), and more modest for the high-grade serous (pHR: 1.04 per 5 kg m(-2)) subtype, but only the association with high-grade serous cancers was significant.
  Conclusions: Higher BMI is associated with adverse survival among the majority of women with ovarian cancer.
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- Grant Information:
  R03-CA115195 United States CA NCI NIH HHS; R01-CA61107 United States CA NCI NIH HHS; R01-CA054419 United States CA NCI NIH HHS; P50 CA105009 United States CA NCI NIH HHS; R01-CA95023 United States CA NCI NIH HHS; R03 CA115195 United States CA NCI NIH HHS; P01 CA017054 United States CA NCI NIH HHS; U01 CA069417 United States CA NCI NIH HHS; P01-CA17054 United States CA NCI NIH HHS; N01 CN025403 United States CN NCI NIH HHS; P50-CA159981 United States CA NCI NIH HHS; P50 CA159981 United States CA NCI NIH HHS; P30 CA016056 United States CA NCI NIH HHS; R01 CA087538 United States CA NCI NIH HHS; N01-PC-67001 United States PC NCI NIH HHS; K22-CA138563 United States CA NCI NIH HHS; R01 CA106414 United States CA NCI NIH HHS; M01 RR000056 United States RR NCRR NIH HHS; P30 CA072720 United States CA NCI NIH HHS; R01 CA095023 United States CA NCI NIH HHS; MO1-RR000056 United States RR NCRR NIH HHS; R03-CA113148 United States CA NCI NIH HHS; U01-CA69417 United States CA NCI NIH HHS; R01-CA112523 United States CA NCI NIH HHS; R03 CA113148 United States CA NCI NIH HHS; R01 CA058598 United States CA NCI NIH HHS; R01-CA080742 United States CA NCI NIH HHS; K22 CA138563 United States CA NCI NIH HHS; R01-CA106414 United States CA NCI NIH HHS; R01 CA058860 United States CA NCI NIH HHS; R01 CA080742 United States CA NCI NIH HHS; P30-CA072720 United States CA NCI NIH HHS; R01-CA126841 United States CA NCI NIH HHS; R01-CA058598 United States CA NCI NIH HHS; R01 CA074850 United States CA NCI NIH HHS; R01-CA122443 United States CA NCI NIH HHS; R01CA058860 United States CA NCI NIH HHS; K07 CA092044 United States CA NCI NIH HHS; R01-CA087538 United States CA NCI NIH HHS; K07 CA080668 United States CA NCI NIH HHS; R01-CA074850 United States CA NCI NIH HHS; U01-CA71966 United States CA NCI NIH HHS; P50-CA105009 United States CA NCI NIH HHS; R01 CA083918 United States CA NCI NIH HHS; N01-CN-55424 United States CN NCI NIH HHS; R01-CA83918 United States CA NCI NIH HHS; R01 CA054419 United States CA NCI NIH HHS; R01 CA122443 United States CA NCI NIH HHS; P30 CA015083 United States CA NCI NIH HHS; R01-CA016056 United States CA NCI NIH HHS; R01 CA076016 United States CA NCI NIH HHS; R01 CA092044 United States CA NCI NIH HHS; K07 CA143047 United States CA NCI NIH HHS; K07-CA143047 United States CA NCI NIH HHS; K07-CA095666 United States CA NCI NIH HHS; R01-CA076016 United States CA NCI NIH HHS; K07-CA080668 United States CA NCI NIH HHS; P50-CA136393 United States CA NCI NIH HHS; K07 CA095666 United States CA NCI NIH HHS; R01 CA112523 United States CA NCI NIH HHS; P50 CA136393 United States CA NCI NIH HHS; R01 CA126841 United States CA NCI NIH HHS; P30-CA15083 United States CA NCI NIH HHS
- Contributed Indexing:
  Investigator: D Bowtell; G Chenevix-Trench; A deFazio; D Gertig; A Green; PM Webb; A Green; P Parsons; N Hayward; PM Webb; D Whiteman
- الموضوع:
  Date Created: 20150708 Date Completed: 20151123 Latest Revision: 20240615
- الموضوع:
  20240615
- الرقم المعرف:
  PMC4559823
- الرقم المعرف:
  10.1038/bjc.2015.245
- الرقم المعرف:
  26151456

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Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.

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