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The TF-miRNA Coregulation Network in Oral Lichen Planus.

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  • معلومة اضافية
    • المصدر:
      Publisher: Wiley Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2024- : [Hoboken, NJ] : Wiley
      Original Publication: New York, NY : Hindawi Pub. Co.
    • الموضوع:
      Carcinoma, Squamous Cell/*genetics ; Lichen Planus, Oral/*genetics ; MicroRNAs/*biosynthesis ; Transcription Factors/*genetics; Carcinoma, Squamous Cell/pathology ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Lichen Planus, Oral/pathology ; MicroRNAs/genetics ; Mouth Mucosa/pathology ; Transcriptome/genetics
    • نبذة مختصرة :
      Oral lichen planus (OLP) is a chronic inflammatory disease that affects oral mucosa, some of which may finally develop into oral squamous cell carcinoma. Therefore, pinpointing the molecular mechanisms underlying the pathogenesis of OLP is important to develop efficient treatments for OLP. Recently, the accumulation of the large amount of omics data, especially transcriptome data, provides opportunities to investigate OLPs from a systematic perspective. In this paper, assuming that the OLP associated genes have functional relationships, we present a new approach to identify OLP related gene modules from gene regulatory networks. In particular, we find that the gene modules regulated by both transcription factors (TFs) and microRNAs (miRNAs) play important roles in the pathogenesis of OLP and many genes in the modules have been reported to be related to OLP in the literature.
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    • الرقم المعرف:
      0 (MicroRNAs)
      0 (Transcription Factors)
    • الموضوع:
      Date Created: 20150612 Date Completed: 20160310 Latest Revision: 20181113
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC4433662
    • الرقم المعرف:
      10.1155/2015/731264
    • الرقم المعرف:
      26064947