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Relationship between Urinary Pesticide Residue Levels and Neurotoxic Symptoms among Women on Farms in the Western Cape, South Africa.

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  • المؤلفون: Motsoeneng PM;Motsoeneng PM; Dalvie MA; Dalvie MA
  • المصدر:
    International journal of environmental research and public health [Int J Environ Res Public Health] 2015 Jun 02; Vol. 12 (6), pp. 6281-99. Date of Electronic Publication: 2015 Jun 02.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel : MDPI, c2004-
    • الموضوع:
      Neurotoxicity Syndromes/*urine ; Occupational Exposure/*adverse effects ; Pesticide Residues/*toxicity ; Pyrethrins/*toxicity; Adult ; Agriculture ; Benzoates/urine ; Cross-Sectional Studies ; Environmental Exposure ; Female ; Humans ; Middle Aged ; Neurotoxicity Syndromes/epidemiology ; Neurotoxicity Syndromes/etiology ; Occupational Exposure/analysis ; Pesticide Residues/urine ; Pesticides/urine ; Phenyl Ethers/urine ; Prevalence ; Pyrethrins/urine ; Rural Population ; South Africa/epidemiology
    • نبذة مختصرة :
      Background: This cross-sectional study aimed to investigate the relationship between urinary pesticide residue levels and neurotoxic symptoms amongst women working on Western Cape farms in South Africa.
      Method: A total of 211 women were recruited from farms (n=121) and neighbouring towns (n=90). Participant assessment was via a Q16 questionnaire, reporting on pesticide exposures and measurement of urinary OP metabolite concentrations of dialkyl phosphates (DAP) and chlorpyriphos, 3,5,6-trichloropyridinol (TCPY) and of pyrethroid (PYR) metabolite concentrations (3- phenoxybenzoic acid (3PBA), 4-fluoro-3-phenoxybenzoic acid (4F3PBA), cis-2,2-dibromovinyl-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA), and the cis- and trans isomers of 2,2-dichlorovinyl-2,2-dimethylcyclopropane-1-carboxylic acid.
      Results: Median urinary pesticide metabolites were slightly (6%-49%) elevated in the farm group compared to the town group, with 2 metabolites significantly higher and some lower in the farm group. The prevalence of all Q16 symptoms was higher amongst farm women compared to town women. Three Q16 symptoms (problems with buttoning, reading and notes) were significantly positively associated with three pyrethroid metabolites (cis- and trans-DCCA and DBCA), although associations may due to chance as multiple comparisons were made. The strongest association for a pyrethroid metabolite was between problems with buttoning and DBCA (odds ratio (OR)=8.93, 95% confidence interval (CI):1.71-46.5. There was no association between Q16 symptoms and OP metabolites.
      Conclusions: Women farm residents and rural women from neighbouring towns in the Western Cape are exposed to OP and PYR pesticides. The study did not provide strong evidence that pesticides are associated with neurotoxic symptoms but associations found could be explored further.
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    • Contributed Indexing:
      Keywords: Q16; female farm workers; neurotoxic symptoms; neurotoxicity; organophosphates; pesticides; pyrethroid
    • الرقم المعرف:
      0 (Benzoates)
      0 (Pesticide Residues)
      0 (Pesticides)
      0 (Phenyl Ethers)
      0 (Pyrethrins)
      2215-77-2 (4-carboxybiphenyl ether)
      69DC2655VH (3-phenoxybenzoic acid)
    • الموضوع:
      Date Created: 20150605 Date Completed: 20160509 Latest Revision: 20181202
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC4483701
    • الرقم المعرف:
      10.3390/ijerph120606281
    • الرقم المعرف:
      26042367