Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Effect of aspect ratio on the uptake and toxicity of hydroxylated-multi walled carbon nanotubes in the nematode, Caenorhabditis elegans.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • المؤلفون: Eom HJ;Eom HJ; Jeong JS; Jeong JS; Choi J; Choi J
  • المصدر:
    Environmental health and toxicology [Environ Health Toxicol] 2015 Mar 05; Vol. 30, pp. e2015001. Date of Electronic Publication: 2015 Mar 05 (Print Publication: 2015).
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Korean Society of Environmental Health and Toxicology Country of Publication: Korea (South) NLM ID: 101570455 Publication Model: eCollection Cited Medium: Print ISSN: 2233-6567 (Print) Linking ISSN: 22336567 NLM ISO Abbreviation: Environ Health Toxicol Subsets: PubMed not MEDLINE
    • بيانات النشر:
      Original Publication: [Korea] : Korean Society of Environmental Health and Toxicology
    • نبذة مختصرة :
      Objectives: In this study, the effect of tube length and outer diameter (OD) size of hydroxylated-multi walled carbon nanotubes (OH-MWCNTs) on their uptake and toxicity was investigated in the nematode Caenorhabditis elegans using a functional mutant analysis.
      Methods: The physicochemical properties of three different OH-MWCNTs were characterized. Uptake and toxicity were subsequently investigated on C. elegans exposed to MWCNTs with different ODs and tube lengths.
      Results: The results of mutant analysis suggest that ingestion is the main route of MWCNTs uptake. We found that OH-MWCNTs with smaller ODs were more toxic than those with larger ODs, and OH-MWCNTs with shorter tube lengths were more toxic than longer counterparts to C. elegans.
      Conclusions: Overall the results suggest the aspect ratio affects the toxicity of MWCNTs in C. elegans. Further thorough study on the relationship between physicochemical properties and toxicity needs to be conducted for more comprehensive understanding of the uptake and toxicity of MWCNTs.
    • References:
      Chem Res Toxicol. 2012 Jan 13;25(1):74-82. (PMID: 22128750)
      Carbon N Y. 2008 Mar;46(3):489-500. (PMID: 19255622)
      Toxicol Sci. 2006 Jul;92(1):5-22. (PMID: 16484287)
      Nat Nanotechnol. 2007 Dec;2(12):751-60. (PMID: 18654426)
      Biomaterials. 2013 Jul;34(22):5661-9. (PMID: 23623425)
      Nat Nanotechnol. 2008 Jul;3(7):423-8. (PMID: 18654567)
      Nano Lett. 2008 Jun;8(6):1577-85. (PMID: 18491944)
      Int J Nanomedicine. 2012;7:5361-74. (PMID: 23091380)
      Inhal Toxicol. 2010 Mar;22(4):340-7. (PMID: 20064106)
      Part Fibre Toxicol. 2010 Mar 22;7:5. (PMID: 20307263)
      Small. 2008 Jan;4(1):26-49. (PMID: 18165959)
      ACS Nano. 2010 Mar 23;4(3):1481-92. (PMID: 20175510)
      Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L552-65. (PMID: 18658273)
      Chem Commun (Camb). 2005 Feb 7;(5):571-7. (PMID: 15672140)
      Environ Pollut. 2010 May;158(5):1748-55. (PMID: 19962802)
      Toxicol Sci. 2008 Nov;106(1):5-28. (PMID: 18566021)
      Nano Lett. 2004 Mar;4(3):507-511. (PMID: 21394241)
      Chem Res Toxicol. 2011 Nov 21;24(11):2028-39. (PMID: 21978239)
      Aquat Toxicol. 2010 Oct 15;100(2):211-7. (PMID: 20732719)
      Environ Sci Technol. 2009 Apr 1;43(7):2322-7. (PMID: 19452881)
      Environ Health Perspect. 2007 Aug;115(8):1125-31. (PMID: 17687437)
      Neurotoxicology. 2012 Oct;33(5):1128-34. (PMID: 22728153)
      Toxicology. 2010 Jun 4;272(1-3):11-6. (PMID: 20371264)
      Inflammation. 2010 Aug;33(4):276-80. (PMID: 20174859)
      Int J Nanomedicine. 2012;7:3731-9. (PMID: 22904621)
      Nanoscale. 2014 Apr 21;6(8):4275-84. (PMID: 24614909)
      Theranostics. 2012;2(3):271-82. (PMID: 22509195)
      Part Fibre Toxicol. 2011 Jan 21;8:3. (PMID: 21255417)
      Nanomedicine (Lond). 2010 Aug;5(6):963-74. (PMID: 20735230)
      Arch Toxicol. 2011 Jul;85(7):775-86. (PMID: 20617304)
      Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1330-8. (PMID: 22084097)
      Chem Rev. 2006 Mar;106(3):1105-36. (PMID: 16522018)
      Environ Sci Technol. 2008 Oct 1;42(19):7528-34. (PMID: 18939597)
      Environ Sci Technol. 2009 May 15;43(10):3933-40. (PMID: 19544910)
      Chem Biol Interact. 2015 Sep 5;239:153-63. (PMID: 26111764)
    • Grant Information:
      P40 OD010440 United States OD NIH HHS
    • Contributed Indexing:
      Keywords: Aspect ratio; Caenorhabditis elegans; Functional genomics; Functionalized multiwall carbon nanotubes
    • الموضوع:
      Date Created: 20150523 Date Completed: 20151125 Latest Revision: 20200930
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC4590576
    • الرقم المعرف:
      10.5620/eht.e2015001
    • الرقم المعرف:
      25997507