Nutritional recovery with a soybean diet after weaning reduces lipogenesis but induces inflammation in the liver in adult rats exposed to protein restriction during intrauterine life and lactation.

Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 9209001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1466-1861 (Electronic) Linking ISSN: 09629351 NLM ISO Abbreviation: Mediators Inflamm Subsets: MEDLINE

Publication: 2005- : Sylvania, OH : Hindawi Pub. Corp.
Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., c1992-

Animal Nutritional Physiological Phenomena* ; Prenatal Nutritional Physiological Phenomena*; Inflammation/*pathology ; Liver/*drug effects ; Glycine max/*chemistry; Animals ; Cell Nucleus/metabolism ; Diet, Protein-Restricted ; Female ; Homeostasis ; Insulin/blood ; Lactation ; Lipids/blood ; Lipogenesis ; Lipolysis ; Liver/metabolism ; Male ; Multienzyme Complexes/chemistry ; NF-kappa B/metabolism ; Oxo-Acid-Lyases/chemistry ; PPAR gamma/metabolism ; Pregnancy ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Sterol Regulatory Element Binding Protein 1/metabolism ; Weaning

We evaluated the effects of postweaning nutritional recovery with a soybean flour diet on de novo hepatic lipogenesis and inflammation in adult rats exposed to protein restriction during intrauterine life and lactation. Rats from mothers fed with protein (casein) in a percentage of 17% (control, C) or 6% (low, L) during pregnancy and lactation were fed with diet that contained 17% casein (CC and LC groups, resp.) or soybean (CS and LS groups, resp.) after weaning until 90 days of age. LS and CS rats had low body weight, normal basal serum triglyceride levels, increased ALT concentrations, and high HOMA-IR indices compared with LC and CC rats. The soybean diet reduced PPARγ as well as malic enzyme and citrate lyase contents and activities. The lipogenesis rate and liver fat content were lower in LS and CS rats relative to LC and CC rats. TNFα mRNA and protein levels were higher in LS and CS rats than in LC and CC rats. NF-κB mRNA levels were lower in the LC and LS groups compared with the CC and LC groups. Thus, the soybean diet prevented hepatic steatosis at least in part through reduced lipogenesis but resulted in TNFα-mediated inflammation.

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0 (Insulin)
0 (Lipids)
0 (Multienzyme Complexes)
0 (NF-kappa B)
0 (PPAR gamma)
0 (RNA, Messenger)
0 (Sterol Regulatory Element Binding Protein 1)
EC 4.1.3.- (Oxo-Acid-Lyases)
EC 4.1.3.6 (citrate (pro-3S)-lyase)

Date Created: 20150421 Date Completed: 20160201 Latest Revision: 20231213

20231215

PMC4393912

10.1155/2015/781703

25892856