Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates.

Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE

Publication: : Oxford : Wiley-Blackwell
Original Publication: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press, c1989-

Evoked Potentials, Somatosensory* ; Neuronal Plasticity*; Neocortex/*physiology ; Neurons/*physiology; Animals ; Cells, Cultured ; Male ; Mice ; Mice, Inbred C57BL ; Neocortex/cytology ; Vibrissae/innervation

Although subthreshold inputs of neocortical sensory neurons are broadly tuned, the spiking output is more restricted. These subthreshold inputs provide a substrate for stimulus intensity-dependent changes their spiking output, as well as for experience-dependent plasticity to alter firing properties. Here we investigated how different stimulus intensities modified the firing output of individual neurons in layer 2/3 of the mouse barrel cortex. Decreasing stimulus intensity over a 30-fold range lowered the firing rates evoked by principal whisker stimulation and reduced the overall size of the responding ensemble in whisker-undeprived animals. We then examined how these responses were changed after single-whisker experience (SWE). After 7 days of SWE, the mean magnitude of response to spared whisker stimulation at the highest stimulus intensity was not altered. However, lower-intensity whisker stimulation revealed a more than 10-fold increase in mean firing output compared with control animals. Also, under control conditions, only ~15% of neurons showed any firing at low stimulus intensity, compared with more than 70% of neurons after SWE. However, response changes measured in the immediately surrounding representations were detected only for the highest stimulus intensity. Overall, these data showed that the measurement of experience-dependent changes in the spike output of neocortical neurons was highly dependent upon stimulus intensity.
(© 2014 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)

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R01 DA017188 United States DA NIDA NIH HHS; BB/J018422/1 United Kingdom Biotechnology and Biological Sciences Research Council; DA0171-88 United States DA NIDA NIH HHS

Keywords: cortical circuitry; glutamatergic neurotransmission; learning and memory; mouse; neocortex; plasticity

Date Created: 20141230 Date Completed: 20151026 Latest Revision: 20181113

20250114

PMC4331261

10.1111/ejn.12805

25546174