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Serum gamma - glutamyltransferase is associated with albuminuria: a population-based study.

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  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science
    • الموضوع:
      Albuminuria/*genetics ; Endothelium/*enzymology ; Population/*genetics ; gamma-Glutamyltransferase/*genetics; Adult ; Age Factors ; Aged ; Albuminuria/epidemiology ; Albuminuria/urine ; Body Mass Index ; China ; Cholesterol/blood ; Creatinine/blood ; Endothelium/pathology ; Female ; Glomerular Filtration Rate ; Humans ; Hypertension/blood ; Hypertension/pathology ; Hypertension/urine ; Male ; Middle Aged ; gamma-Glutamyltransferase/blood
    • نبذة مختصرة :
      Background: Serum γ - glutamyltransferase (GGT) is implicated in the pathogenesis of endothelial dysfunction and atherosclerosis. Albuminuria is a marker of endothelial damage and correlated with structural and functional integrity of the vasculature. Our objective was to evaluate the association between serum GGT level and prevalence of albuminuria in a Chinese population.
      Materials and Methods: We conducted a population-based cross-sectional study in 9,702 subjects aged 40 years or older. Increased urinary albumin excretion was defined according to the urinary albumin-to-creatinine ratio (ACR) ranges greater or equal than 30 mg/g. Low-grade albuminuria was defined according to the highest quartile of ACR in participants without increased urinary albumin excretion.
      Results: The prevalence of low-grade albuminuria and increased urinary albumin excretion were respectively 23.4% and 6.6% in this population and gradually increased across the sex-specific serum GGT quartiles (all P for trend <0.05). In logistic regression analysis, compared with subjects in the lowest quartile of serum GGT level, the adjusted odds ratios (ORs) in the highest quartile was 1.22 [95% confidence interval (CI), 1.04-1.43] for low-grade albuminuria and 1.55 (95% CI, 1.18-2.04) for increased urinary albumin excretion. In subgroup analysis, significant relationship of serum GGT level with both low-grade albuminuria and increased urinary albumin excretion were detected in women, younger subjects, overweight subjects and in those with hypertension or glomerular filtration rate greater than 90 (all P <0.05).
      Conclusion: Serum GGT level is associated with urinary albumin excretion in middle-aged and elderly Chinese.
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    • الرقم المعرف:
      97C5T2UQ7J (Cholesterol)
      AYI8EX34EU (Creatinine)
      EC 2.3.2.2 (gamma-Glutamyltransferase)
    • الموضوع:
      Date Created: 20141216 Date Completed: 20151221 Latest Revision: 20181113
    • الموضوع:
      20240628
    • الرقم المعرف:
      PMC4263709
    • الرقم المعرف:
      10.1371/journal.pone.0114970
    • الرقم المعرف:
      25500578