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Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity.

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  • معلومة اضافية
    • المصدر:
      Publisher: Hindawi Country of Publication: India NLM ID: 100883691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1462-5822 (Electronic) Linking ISSN: 14625814 NLM ISO Abbreviation: Cell Microbiol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2022- : Mumbai : Hindawi
      Original Publication: Oxford : Wiley-Blackwell, c1999-
    • الموضوع:
      Candida albicans/*cytology ; Candida albicans/*physiology ; Candidiasis/*immunology ; Candidiasis/*microbiology ; Gastrointestinal Tract/*immunology ; Gastrointestinal Tract/*microbiology ; Th17 Cells/*immunology; Animals ; Candida albicans/growth & development ; Candida albicans/immunology ; Disease Models, Animal ; Mice
    • نبذة مختصرة :
      The ability of Candida albicans to cause disease is associated with its capacity to undergo morphological transition between yeast and filamentous forms, but the role of morphology in colonization and dissemination from the gastrointestinal (GI) tract remains poorly defined. To explore this, we made use of wild-type and morphological mutants of C. albicans in an established model of GI tract colonization, induced following antibiotic treatment of mice. Our data reveal that GI tract colonization favours the yeast form of C. albicans, that there is constitutive low level systemic dissemination in colonized mice that occurs irrespective of fungal morphology, and that colonization is not controlled by Th17 immunity in otherwise immunocompetent animals. These data provide new insights into the mechanisms of pathogenesis and commensalism of C. albicans, and have implications for our understanding of human disease.
      (© 2014 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd.)
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    • Grant Information:
      102705 United Kingdom WT_ Wellcome Trust; 097377 United Kingdom WT_ Wellcome Trust; 5R01AI083344 United States AI NIAID NIH HHS; 086558 United Kingdom WT_ Wellcome Trust; R01 AI083344 United States AI NIAID NIH HHS; United Kingdom WT_ Wellcome Trust; 102705/Z/13/Z United Kingdom WT_ Wellcome Trust; 101873 United Kingdom WT_ Wellcome Trust; 080088 United Kingdom WT_ Wellcome Trust
    • الموضوع:
      Date Created: 20141028 Date Completed: 20151110 Latest Revision: 20230709
    • الموضوع:
      20230710
    • الرقم المعرف:
      PMC4409086
    • الرقم المعرف:
      10.1111/cmi.12388
    • الرقم المعرف:
      25346172