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Plasmodium falciparum, but not P. vivax, can induce erythrocytic apoptosis.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305 (Electronic) Linking ISSN: 17563305 NLM ISO Abbreviation: Parasit Vectors Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central
    • الموضوع:
      Apoptosis/*physiology ; Erythrocytes/*parasitology ; Malaria, Falciparum/*parasitology ; Malaria, Vivax/*parasitology ; Plasmodium falciparum/*physiology ; Plasmodium vivax/*physiology; Erythrocytes/physiology ; Humans ; Parasitemia
    • نبذة مختصرة :
      Background: Apoptosis can occur in red blood cells (RBC) and seems to be involved in hematologic disorders related to many diseases. In malaria it is known that parasitized RBC (pRBC) is involved in the development of anemia and thrombosis; however, non-parasitized RBC (nRBC) apoptosis could amplify these malaria-associated hematologic events. In fact, in experimental malaria, increased levels of apoptosis were observed in nRBC during lethal Plasmodium yoelii 17XL infection, but in human malaria erythrocytic apoptosis has never been studied. The present study was performed to investigate if nRBC apoptosis also occurs in P. vivax and P. falciparum infections.
      Findings: Apoptosis of nRBC was evaluated in blood samples of P. vivax malaria patients and clinically healthly individuals living in Manaus, Brazil, both ex vivo and after incubation of RBC for 24 h. Additionally, the capacity of plasma from P. vivax or P. falciparum patients was tested for induction of in vitro apoptosis of normal RBC from a clinically healthy individual living in a non-endemic malaria region. Apoptosis was detected by flow cytometry using annexin V staining. In contrast to experimental malaria that significantly increased the levels of apoptotic nRBC both ex-vivo and after 24 h of incubation, no significant alteration on apoptotic nRBC rates was detected in P. vivax infected patients when compared with non-infected control individuals. Similar results were observed when plasma of these P. vivax patients was incubated with normal RBC. Conversely, plasma from P. falciparum-infected subjects induced significant apoptosis of these cells.
      Conclusions: Apoptosis of normal RBC can be induced by plasma from individuals with P. falciparum (but not with P. vivax) malaria. This finding could reflect the existence of erythrocytic apoptosis during infection that could contribute to the pathogenesis of hematological and vascular complications associated with falciparum malaria.
    • References:
      PLoS Med. 2008 Jun 17;5(6):e128. (PMID: 18563962)
      Nat Med. 2011 Jan;17(1):48-9. (PMID: 21217683)
      Mem Inst Oswaldo Cruz. 2013 Sep;108(6):686-90. (PMID: 24037189)
      PLoS One. 2012;7(4):e35406. (PMID: 22523591)
      Adv Parasitol. 2012;80:151-201. (PMID: 23199488)
      Transfus Med Hemother. 2012 Oct;39(5):308-14. (PMID: 23801921)
      Cell Physiol Biochem. 2008;22(1-4):261-8. (PMID: 18769053)
      Cell Physiol Biochem. 2002;12(5-6):373-84. (PMID: 12438774)
      Malar J. 2010 Dec 02;9:350. (PMID: 21126362)
      Parasit Vectors. 2012 Jul 30;5:154. (PMID: 22846165)
      Clin Lab Med. 2010 Mar;30(1):93-129. (PMID: 20513543)
      Cytometry. 2001 May 1;44(1):65-72. (PMID: 11309810)
      PLoS One. 2012;7(9):e44394. (PMID: 22973442)
      Mem Inst Oswaldo Cruz. 2014 Aug;109(5):618-33. (PMID: 25185003)
      Cytometry A. 2005 Jul;66(1):78-84. (PMID: 15915509)
      Blood. 2002 Mar 1;99(5):1564-71. (PMID: 11861269)
      Br J Haematol. 1999 Nov;107(2):300-2. (PMID: 10583215)
      Trends Cell Biol. 2006 Apr;16(4):189-97. (PMID: 16529932)
      Expert Rev Mol Med. 2006 Mar 23;8(6):1-22. (PMID: 16556343)
      PLoS One. 2011;6(12):e29203. (PMID: 22216212)
      Acta Trop. 2009 Nov;112(2):236-8. (PMID: 19665984)
      Malar J. 2010 Apr 30;9:115. (PMID: 20433744)
      Cell Death Differ. 2001 Dec;8(12):1143-56. (PMID: 11753563)
      J Immunol Methods. 1995 Jul 17;184(1):39-51. (PMID: 7622868)
      Am J Trop Med Hyg. 2003 Oct;69(4):345-59. (PMID: 14640492)
      J Thromb Haemost. 2011 May;9(5):1049-55. (PMID: 21362128)
    • الموضوع:
      Date Created: 20141019 Date Completed: 20151117 Latest Revision: 20211021
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC4206708
    • الرقم المعرف:
      10.1186/s13071-014-0484-8
    • الرقم المعرف:
      25325923