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Association of Superoxide dismutases (SOD1 and SOD2) and Glutathione peroxidase 1 (GPx1) gene polymorphisms with type 2 diabetes mellitus.

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  • المؤلفون: Vats P;Vats P; Sagar N; Singh TP; Banerjee M
  • المصدر:
    Free radical research [Free Radic Res] 2015 Jan; Vol. 49 (1), pp. 17-24. Date of Electronic Publication: 2014 Oct 31.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 9423872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2470 (Electronic) Linking ISSN: 10292470 NLM ISO Abbreviation: Free Radic Res Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Yverdon, Switzerland : New York, NY : Harwood Academic ; distributed by STBS Ltd., c1994-
    • الموضوع:
      Diabetes Mellitus, Type 2/*enzymology ; Diabetes Mellitus, Type 2/*genetics ; Glutathione Peroxidase/*genetics ; Superoxide Dismutase/*genetics; Case-Control Studies ; Demography ; Diabetes Mellitus, Type 2/blood ; Genetic Predisposition to Disease ; Genotype ; Glutathione Peroxidase/metabolism ; Humans ; India ; Oxidative Stress/genetics ; Polymorphism, Single Nucleotide ; Superoxide Dismutase/metabolism ; Superoxide Dismutase-1 ; Glutathione Peroxidase GPX1
    • نبذة مختصرة :
      Type 2 diabetes mellitus (T2DM) is a metabolic disorder resulting from oxidative stress (OS), the root cause of insulin resistance, β-cell dysfunction, and impaired glucose tolerance. Antioxidant enzymes play key roles in cellular defense and can be used as important biomarkers for T2DM. The present study was undertaken to evaluate three genetic polymorphisms viz. SOD1 + 35A/C, SOD2 + 47C/T, and GPx + 599C/T in 207 T2DM cases and 210 healthy controls from North India. DNA was extracted from blood samples and genotyping was done by PCR-RFLP. Genotypic/allelic frequencies and haplotype/gene-gene interaction analysis were performed using SPSS (version 15.0) and SHEsis (v. online). Except age, all other biochemical parameters showed highly significant association in T2DM cases (P < 0.001). In North Indian population, SOD1 + 35A/C variant was monomorphic. Genotype/allele frequencies of SOD2 + 47C/T polymorphism and carriage rate of 'C' allele showed significant association (p < 0.05, < 0.001; OR 2.434). Genotype/allele frequencies of GPx1 + 599C/T and carriage rate showed no association although the odds ratio of GPx1 'C' allele indicated a 1.362 times higher risk of T2DM. SOD2 'CT' and GPx1 'CC' genotypes showed maximum association with biochemical parameters. Haplotype/gene-gene interaction analysis in controls and cases showed that SOD2 + 47C/T and GPx1 + 599C/T were in linkage disequilibrium (D: 0.168; r(2): 0.10) and individuals with this combination had a 1.273 times higher risk [OR; CI (95%)] of developing T2DM. Thus, we conclude that it is essential to assess the combinatorial association of gene variants with T2DM in order to identify risk haplotypes in a population.
    • Contributed Indexing:
      Keywords: Type 2 diabetes mellitus; antioxidant enzymes; gene polymorphism; oxidative stress; reactive metabolites
    • الرقم المعرف:
      0 (SOD1 protein, human)
      EC 1.11.1.9 (Glutathione Peroxidase)
      EC 1.15.1.1 (Superoxide Dismutase)
      EC 1.15.1.1 (Superoxide Dismutase-1)
      EC 1.15.1.1 (superoxide dismutase 2)
      EC 1.11.1.9 (Glutathione Peroxidase GPX1)
      EC 1.11.1.9 (GPX1 protein, human)
    • الموضوع:
      Date Created: 20141007 Date Completed: 20150805 Latest Revision: 20221207
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.3109/10715762.2014.971782
    • الرقم المعرف:
      25283363