Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe.

Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE

Publication: <2002->: New York, NY : Nature Publishing Group
Original Publication: New York, NY : Nature America Inc., c1998-

Brain Mapping*; Orientation/*physiology ; Parietal Lobe/*physiology ; Space Perception/*physiology ; Spatial Behavior/*physiology; Adolescent ; Adult ; Female ; Humans ; Image Processing, Computer-Assisted/methods ; Learning/physiology ; Magnetic Resonance Imaging/methods ; Male ; Mental Recall/physiology ; Young Adult

The neural systems that code for location and facing direction during spatial navigation have been investigated extensively; however, the mechanisms by which these quantities are referenced to external features of the world are not well understood. To address this issue, we examined behavioral priming and functional magnetic resonance imaging activity patterns while human subjects recalled spatial views from a recently learned virtual environment. Behavioral results indicated that imagined location and facing direction were represented during this task, and multivoxel pattern analyses indicated that the retrosplenial complex (RSC) was the anatomical locus of these spatial codes. Critically, in both cases, location and direction were defined on the basis of fixed elements of the local environment and generalized across geometrically similar local environments. These results suggest that RSC anchors internal spatial representations to local topographical features, thus allowing us to stay oriented while we navigate and retrieve from memory the experience of being in a particular place.

Comment in: Nat Neurosci. 2014 Nov;17(11):1436-7. (PMID: 25349907)
Erratum in: Nat Neurosci. 2015 Jun;18(6):926. (PMID: 26007214)

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R01 EY022350 United States EY NEI NIH HHS; EY022350 United States EY NEI NIH HHS

Date Created: 20141006 Date Completed: 20150112 Latest Revision: 20220309

20231215

PMC4309016

10.1038/nn.3834

25282616