Inflammation profile in overweight/obese adolescents in Europe: an analysis in relation to iron status.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8804070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5640 (Electronic) Linking ISSN: 09543007 NLM ISO Abbreviation: Eur J Clin Nutr Subsets: MEDLINE

Publication: <2003->: London : Nature Publishing Group
Original Publication: London : J. Libbey, c1988-

Anemia, Iron-Deficiency*/blood ; Anemia, Iron-Deficiency*/etiology ; Body Mass Index* ; Iron Deficiencies*; Adipose Tissue/*metabolism ; C-Reactive Protein/*metabolism ; Inflammation/*etiology ; Obesity/*complications; Adiposity ; Adolescent ; Biomarkers/blood ; Cross-Sectional Studies ; Diet ; Dietary Proteins/administration & dosage ; Europe ; Female ; Ferritins/blood ; Humans ; Inflammation/blood ; Male ; Nutritional Status ; Obesity/blood ; Obesity/metabolism ; Orosomucoid/metabolism ; Overweight ; Sex Factors ; Transferrin/metabolism

Background/objectives: The objectives of this study were to investigate the relationship between inflammatory parameters (CRP, c-reactive protein; AGP, α1-acid glycoprotein), iron status indicators (SF, serum ferritin; sTfR, soluble transferrin receptor) and body mass index (BMI) z-score, fat-free mass (FFM) and fat mass (FM) in European adolescents. Differences in intake for some nutrients (total iron, haem and non-haem iron, vitamin C, calcium, proteins) were assessed according to BMI categories, and the association of nutrient intakes with BMI z-score, FM and FFM was evaluated.
Methods: A total of 876 adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence-Cross Sectional Study were included in the study sample.
Results: Mean CRP values (standard error; s.e.) were significantly higher in overweight/obese adolescents (1.7±0.3 and 1.4±0.3 mg/l in boys and girls, respectively) than in thin/normal-weight adolescents (1.1±0.2 and 1.0±0.1 mg/l in boys and girls, respectively) (P<0.05). For boys, mean SF values (s.e.) were significantly higher in overweight/obese adolescents (46.9±2.7 μg/l) than in thin/normal-weight adolescents (35.7±1.7 μg/l) (P<0.001), whereas median sTfR values did not differ among BMI categories for both boys and girls. Multilevel regression analyses showed that BMI z-score and FM were significantly related to CRP and AGP (P<0.05). Dietary variables did not differ significantly among BMI categories, except for the intake of vegetable proteins, which, for boys, was higher in thin/normal-weight adolescents than in overweight/obese adolescents (P<0.05).
Conclusions: The adiposity of the European adolescents was sufficient to cause chronic inflammation but not sufficient to impair iron status and cause iron deficiency.

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001 International WHO_ World Health Organization

Investigator: LA Moreno; F Gottrand; S De Henauw; M González-Gross; C Gilbert; A Kafatos; LA Moreno; C Libersa; S De Henauw; J Sáchez; F Gottrand; M Kesting; M Sjostrom; D Molnár; M González-Gross; J Dallongeville; C Gilbert; G Hall; L Maes; L Scalfi; P Meléndez; LA Moreno; J Fleta; JA Casajús; G Rodríguez; C Tomás; MI Mesana; G Vicente-Rodríguez; A Villarroya; CM Gil; I Ara; J Revenga; C Lachen; J Fernández Alvira; G Bueno; Aurora Lázaro; O Bueno; JF León; JM Garagorri; M Bueno; JP López; I Iglesia; P Velasco; S Bel; A Marcos; J Wärnberg; E Nova; S Gómez; EL Díaz; J Romeo; A Veses; MA Puertollano; B Zapatera; T Pozo; L Beghin; C Libersa; F Gottrand; C Iliescu; J Von Berlepsch; M Kersting; W Sichert-Hellert; E Koeppen; D Molnar; E Erhardt; K Csernus; K Török; S Bokor; E Nagy; O Kovács; J Repásy; A Kafatos; C Codrington; M Plada; A Papadaki; K Sarri; A Viskadourou; C Hatzis; M Kiriakakis; G Tsibinos; CV Sbokos; E Protoyeraki; M Fasoulaki; P Stehle; K Pietrzik; M González-Gross; C Breidenassel; A Spinneker; J Al-Tahan; M Segoviano; A Berchtold; C Bierschbach; E Blatzheim; A Schuch; P Picker; MJ Castillo; Á Gutiérrez; FB Ortega; JR Ruiz; EG Artero; V España-Romero; D Jiménez-Pavón; P Chillón; M Cuenca-Garcia; D Arcella; E Azzini; E Barrison; N Bevilacqua; P Buonocore; G Catasta; L Censi; D Ciarapica; P D'Acapito; M Ferrari; M Galfo; CL Donne; C Leclercq; G Maiani; B Mauro; L Mistura; A Pasquali; R Piccinelli; A Polito; R Spada; S Sette; M Zaccaria; L Scalfi; P Vitaglione; C Montagnese; S De Henauw; T De Vriendt; L Maes; C Matthys; C Vereecken; M de Maeyer; C Ottevaere; I Huybrechts; K Widhalm; K Phillipp; S Dietrich; Y Manios; E Grammatikaki; Z Bouloubasi; TL Cook; O Consta; G Moschonis; I Katsaroli; G Kraniou; S Papoutsou; D Keke; I Petraki; E Bellou; S Tanagra; K Kallianoti; D Argyropoulou; K Kondaki; S Tsikrika; C Karaiskos; J Dallongeville; A Meirhaeghe; M Sjöstrom; P Bergman; M Hagströmer; L Hallström; M Hallberg; E Poortvliet; J Wärnberg; N Rizzo; L Beckman; AH Wennlöf; E Patterson; L Kwak; L Cernerud; P Tillgren; S Sörensen; J Sánchez-Molero; E Picó; M Navarro; B Viadel; JE Carreres; G Merino; R Sanjuán; M Lorente; MJ Sánchez; C Gilbert; S Thomas; E Allchurch; P Burgess; G Hall; A Astrom; A Sverkén; A Broberg; A Masson; C Lehoux; P Brabant; P Pate; L Fontaine; A Sebok; T Kuti; A Hegyi; C Maldonado; A Llorente; E García; H von Fircks; ML Hallberg; M Messerer; M Larsson; H Fredriksson; V Adamsson; I Börjesson; L Fernández; L Smillie; J Wills; M González-Gross; J Valtueña; D Jiménez-Pavón; U Albers; R Pedrero; A Meléndez; PJ Benito; JJ Gómez Lorente; D Cañada; A Urzanqui; JC Ortiz; F Fuentes; RM Torres; P Navarro

0 (Biomarkers)
0 (Dietary Proteins)
0 (Orosomucoid)
0 (Transferrin)
9007-41-4 (C-Reactive Protein)
9007-73-2 (Ferritins)

Date Created: 20140911 Date Completed: 20150928 Latest Revision: 20240324

20240324

10.1038/ejcn.2014.154

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