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Synthesis, colloidal properties and cytotoxicity of biopolymer nanoparticles.

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  • المؤلفون: Moorkoth D;Moorkoth D; Nampoothiri KM
  • المصدر:
    Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2014 Nov; Vol. 174 (6), pp. 2181-94. Date of Electronic Publication: 2014 Aug 30.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Clifton, N.J. : Humana Press, c1981-
    • الموضوع:
      Biopolymers/*chemistry ; Biopolymers/*toxicity ; Drug Carriers/*chemistry ; Drug Carriers/*toxicity ; Nanoparticles/*chemistry; Animals ; CHO Cells ; Chemistry Techniques, Synthetic ; Colloids ; Cricetinae ; Cricetulus ; Drug Carriers/chemical synthesis ; Drug Liberation ; Drug Stability ; Lactic Acid/chemistry ; Particle Size
    • نبذة مختصرة :
      To characterize the physicochemical and biological stability of nanodevices suitable for biomedical applications, polylactic acid (PLA) nanoparticles (NPs) of 112 ± 6 nm and polyhydroxy butyrate (PHB) of 15 ± 5 nm size were prepared by standardizing the suitable method for each. Morphology of NPs was studied by scanning and transmission electron microscopy and temperature stability by thermogravimetric analysis. Their stability in biological fluids (simulated gastrointestinal and saliva) and tolerance against 0.5 mM NaCl were analyzed. PHB NPs remained stable in all fluids, while after 24 h treatment, the PLA NPs showed the beginning of disintegration with intestinal fluid mimic. In addition to the preparation of polyethylene glycol (PEG) surface-coated NPs, PLA-PEG-PLA triblock copolymer (MW ∼ 7,366 Da) was also chemically synthesized and characterized. Cytotoxicity of all forms of nanoparticles was tested by MTT assay and by annexin pi staining.
    • الرقم المعرف:
      0 (Biopolymers)
      0 (Colloids)
      0 (Drug Carriers)
      33X04XA5AT (Lactic Acid)
    • الموضوع:
      Date Created: 20140831 Date Completed: 20150619 Latest Revision: 20141024
    • الموضوع:
      20240628
    • الرقم المعرف:
      10.1007/s12010-014-1172-z
    • الرقم المعرف:
      25172058