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Risk factors for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Huang AM;Huang AM; Marini BL; Frame D; Aronoff DM; Nagel JL
  • المصدر:
    Transplant infectious disease : an official journal of the Transplantation Society [Transpl Infect Dis] 2014 Oct; Vol. 16 (5), pp. 744-50. Date of Electronic Publication: 2014 Jul 18.
  • نوع النشر :
    Journal Article; Research Support, N.I.H., Extramural
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Munksgaard Country of Publication: Denmark NLM ID: 100883688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3062 (Electronic) Linking ISSN: 13982273 NLM ISO Abbreviation: Transpl Infect Dis Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Copenhagen : Munksgaard, c1999-
    • الموضوع:
      Clostridioides difficile*; Enterocolitis, Pseudomembranous/*epidemiology ; Hematopoietic Stem Cell Transplantation/*adverse effects ; Neutropenia/*epidemiology; Adult ; Aged ; Case-Control Studies ; Enterocolitis, Pseudomembranous/microbiology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Recurrence ; Retrospective Studies ; Risk Factors ; Time Factors ; Young Adult
    • نبذة مختصرة :
      Background: Recurrent Clostridium difficile infection (CDI) represents a significant burden on the healthcare system and is associated with poor outcomes in hematopoietic stem cell transplant (HSCT) patients. Data are limited evaluating recurrence rates and risk factors for recurrence in HSCT patients.
      Methods: HSCT patients who developed CDI between January 2010 and December 2012 were divided into 2 groups: non-recurrent CDI (nrCDI) and recurrent CDI (rCDI). Risk factors for rCDI were compared between groups. Rate of recurrence in HSCT patients was compared to that in other hospitalized patients.
      Results: CDI was diagnosed in 95 of 711 HSCT patients (22 rCDI and 73 nrCDI). Recurrence rates were similar in HSCT patients compared with other hospitalized patients (23.2% vs. 22.9%, P > 0.99). Patients in the rCDI group developed the index case of CDI significantly earlier than the nrCDI group (3.5 days vs. 7.0 days after transplant, P = 0.05). On univariate analysis, patients with rCDI were more likely to have prior history of CDI and neutropenia at the time of the index CDI case. Neutropenia at the time of the index CDI case was the only independent predictor of rCDI (78.8 vs. 34.8%, P = 0.006) on multivariate analysis.
      Conclusions: The rate of rCDI was similar between HSCT and other hospitalized patients, and the majority of patients developed the index case of CDI within a week of transplantation. Neutropenia at the index CDI case may be associated with increased rates of rCDI.
      (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
    • Grant Information:
      U19 AI090871 United States AI NIAID NIH HHS; 5U19AI090871-02 United States AI NIAID NIH HHS
    • Contributed Indexing:
      Keywords: recurrence; recurrent Clostridium difficile; stem cell transplant
    • الموضوع:
      Date Created: 20140722 Date Completed: 20150708 Latest Revision: 20211021
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1111/tid.12267
    • الرقم المعرف:
      25040545