Phospholipid transport via mitochondria.

Publisher: Wiley Country of Publication: England NLM ID: 100939340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0854 (Electronic) Linking ISSN: 13989219 NLM ISO Abbreviation: Traffic Subsets: MEDLINE

Publication: Oxford : Wiley
Original Publication: Copenhagen, Denmark ; Malden, MA : Munksgaard, c2000-

Biological Transport/*physiology ; Mitochondria/*metabolism ; Phospholipids/*metabolism; Endoplasmic Reticulum/metabolism ; Membrane Proteins/metabolism ; Mitochondrial Membranes/metabolism

In eukaryotic cells, complex membrane structures called organelles are highly developed to exert specialized functions. Mitochondria are one of such organelles consisting of the outer and inner membranes (OM and IM) with characteristic protein and phospholipid compositions. Maintaining proper phospholipid compositions of the membranes is crucial for mitochondrial integrity, thereby contributing to normal cell activities. As cellular locations for phospholipid synthesis are restricted to specific compartments such as the endoplasmic reticulum (ER) membrane and the mitochondrial inner membrane, newly synthesized phospholipids have to be transported and distributed properly from the ER or mitochondria to other cellular membranes. Although understanding of molecular mechanisms of phospholipid transport are much behind those of protein transport, recent studies using yeast as a model system began to provide intriguing insights into phospholipid exchange between the ER and mitochondria as well as between the mitochondrial OM and IM. In this review, we summarize the latest findings of phospholipid transport via mitochondria and discuss the implicated molecular mechanisms.
(© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

J Biol Chem. 2012 May 4;287(19):15205-18. (PMID: 22403410)
J Biol Chem. 2003 Jul 25;278(30):27781-8. (PMID: 12707284)
J Bacteriol. 1991 Mar;173(6):2026-34. (PMID: 2002005)
Curr Biol. 2009 Dec 29;19(24):2133-9. (PMID: 19962311)
J Cell Biol. 2014 Mar 31;204(7):1083-6. (PMID: 24687277)
EMBO J. 2010 Jun 16;29(12):1976-87. (PMID: 20485265)
J Biol Chem. 1989 May 15;264(14):8019-25. (PMID: 2542259)
Genetics. 2008 Feb;178(2):825-37. (PMID: 18245340)
Traffic. 2012 Jun;13(6):880-90. (PMID: 22409400)
Dev Cell. 2011 Oct 18;21(4):694-707. (PMID: 21944719)
J Cell Biol. 2009 Jan 12;184(1):129-41. (PMID: 19139266)
J Mol Biol. 2011 Nov 4;413(4):743-50. (PMID: 21945531)
Nature. 2003 Oct 16;425(6959):686-91. (PMID: 14562095)
Biochim Biophys Acta. 2012 Aug;1821(8):1068-77. (PMID: 22234261)
J Biol Chem. 2004 Jul 2;279(27):28298-303. (PMID: 15087460)
J Cell Biol. 2008 Dec 29;183(7):1213-21. (PMID: 19114592)
Science. 2012 Nov 9;338(6108):815-8. (PMID: 23042293)
Biochemistry. 2008 Apr 15;47(15):4518-29. (PMID: 18358005)
Trends Cell Biol. 2009 Feb;19(2):81-8. (PMID: 19144519)
J Biol Chem. 1998 Apr 17;273(16):9829-36. (PMID: 9545322)
J Cell Sci. 2002 Jul 1;115(Pt 13):2627-37. (PMID: 12077354)
J Cell Biol. 1997 Feb 10;136(3):545-53. (PMID: 9024686)
EMBO J. 2011 Oct 18;30(21):4356-70. (PMID: 22009199)
Trends Biochem Sci. 2012 Jan;37(1):32-41. (PMID: 22014644)
Biochim Biophys Acta. 2009 Jan;1793(1):212-8. (PMID: 18725250)
Mol Microbiol. 2011 Apr;80(1):248-65. (PMID: 21306442)
Mol Biol Cell. 2003 Jun;14(6):2342-56. (PMID: 12808034)
J Cell Biol. 2006 Jun 5;173(5):651-8. (PMID: 16754953)
J Cell Biol. 1994 Sep;126(6):1375-91. (PMID: 8089172)
J Biol Chem. 2008 Jul 18;283(29):20433-42. (PMID: 18458075)
EMBO J. 2010 Sep 1;29(17):2888-98. (PMID: 20657548)
J Biol Chem. 2012 Oct 26;287(44):36744-55. (PMID: 22984266)
Biochem Soc Trans. 2011 Aug;39(4):1033-8. (PMID: 21787343)
Nat Rev Mol Cell Biol. 2010 Oct;11(10):739-50. (PMID: 20823909)
J Biol Chem. 2012 Dec 21;287(52):43961-71. (PMID: 23124206)
J Biol Chem. 1987 Apr 5;262(10):4876-81. (PMID: 3031032)
J Cell Biol. 2009 Feb 23;184(4):583-96. (PMID: 19221197)
EMBO J. 2010 Sep 1;29(17):2875-87. (PMID: 20622808)
Mol Biol Cell. 2002 Mar;13(3):847-53. (PMID: 11907266)
FEBS Lett. 2006 Oct 16;580(24):5628-34. (PMID: 16997298)
J Cell Biol. 2011 Jan 10;192(1):7-16. (PMID: 21220505)
Trends Cell Biol. 2014 Jan;24(1):44-52. (PMID: 24001776)
J Cell Biol. 2011 Oct 17;195(2):323-40. (PMID: 21987634)
Biochim Biophys Acta. 1997 Apr 3;1325(1):108-16. (PMID: 9106488)
J Biol Chem. 1996 Jan 12;271(2):789-95. (PMID: 8557688)
Prog Lipid Res. 2013 Oct;52(4):590-614. (PMID: 24007978)
J Cell Biol. 1994 Sep;126(6):1361-73. (PMID: 8089171)
J Cell Biol. 2005 Jan 3;168(1):103-15. (PMID: 15631992)
J Bacteriol. 1997 Dec;179(24):7611-6. (PMID: 9401016)
J Cell Biol. 2006 Jul 31;174(3):379-90. (PMID: 16880272)
IUBMB Life. 2010 Jun;62(6):414-28. (PMID: 20503434)
J Biol Chem. 2007 Oct 19;282(42):30562-9. (PMID: 17726007)
J Biol Chem. 2010 Dec 31;285(53):41222-31. (PMID: 21036907)
Science. 2009 Jul 24;325(5939):477-81. (PMID: 19556461)
J Biol Chem. 1998 Jun 12;273(24):14933-41. (PMID: 9614098)
J Biol Chem. 2012 May 18;287(21):17589-17597. (PMID: 22433850)
J Bacteriol. 1983 Apr;154(1):304-11. (PMID: 6300035)
Biochem Biophys Res Commun. 2003 Aug 22;308(2):276-83. (PMID: 12901865)
Nat Rev Mol Cell Biol. 2009 Aug;10(8):513-25. (PMID: 19603039)
J Biol Chem. 2001 Mar 9;276(10):7114-21. (PMID: 11104779)
J Cell Biol. 2003 Feb 3;160(3):303-11. (PMID: 12566426)
Biochem J. 1998 Apr 1;331 ( Pt 1):217-23. (PMID: 9512482)
Autophagy. 2014 Feb;10(2):376-8. (PMID: 24351649)
J Cell Sci. 2012 Oct 15;125(Pt 20):4791-9. (PMID: 22797914)
J Cell Biol. 2004 Mar 1;164(5):677-88. (PMID: 14981098)
Science. 1975 Sep 12;189(4206):867. (PMID: 17812524)
J Biol Chem. 1995 Dec 15;270(50):29836-42. (PMID: 8530379)
Biochim Biophys Acta. 2013 Nov;1833(11):2526-41. (PMID: 23380708)
Bioinformatics. 2010 Aug 15;26(16):1927-31. (PMID: 20554689)
J Lipid Res. 2003 Mar;44(3):441-9. (PMID: 12562848)
Curr Opin Cell Biol. 2011 Aug;23(4):458-63. (PMID: 21555211)
J Cell Biol. 2004 Apr 26;165(2):167-73. (PMID: 15096522)
Biochim Biophys Acta. 2014 Apr 4;1841(4):595-609. (PMID: 24316057)
Nat Cell Biol. 2013 Oct;15(10):1197-1205. (PMID: 24036476)
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7279-83. (PMID: 6316353)
J Cell Sci. 2013 Dec 1;126(Pt 23):5317-23. (PMID: 24190879)
FEBS Lett. 1998 Jan 2;421(1):15-8. (PMID: 9462830)
Genetics. 2012 Feb;190(2):317-49. (PMID: 22345606)
J Cell Biol. 2009 Jun 15;185(6):1029-45. (PMID: 19506038)
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E458-67. (PMID: 23341591)
Mol Biol Cell. 2013 Jun;24(12):2008-20. (PMID: 23637464)
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14151-6. (PMID: 21825164)
J Biol Chem. 2004 Feb 20;279(8):6635-42. (PMID: 14660568)
Biochim Biophys Acta. 1995 Mar 22;1234(2):214-20. (PMID: 7696296)
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15179-83. (PMID: 21896724)
J Cell Sci. 2013 Aug 15;126(Pt 16):3563-74. (PMID: 23781023)
Cell Metab. 2013 May 7;17(5):709-18. (PMID: 23623749)
Biochim Biophys Acta. 1993 Jan 18;1145(1):1-7. (PMID: 8422402)
J Cell Biol. 2001 Jan 22;152(2):401-10. (PMID: 11266455)
Nature. 2003 May 29;423(6939):537-41. (PMID: 12774122)

R01 GM089853 United States GM NIGMS NIH HHS; GM089853 United States GM NIGMS NIH HHS

Keywords: ERMES; Ups protein; cardiolipin; flippase; membrane contact site; mitochondria; phospholipid; scramblase

0 (Membrane Proteins)
0 (Phospholipids)

Date Created: 20140624 Date Completed: 20150709 Latest Revision: 20211021

20250114

PMC4140972

10.1111/tra.12188

24954234