Total synthesis of (+/-)-4-demethylenglerin A.

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المؤلفون: Dong L;Dong L; Jiao XZ; Liu XY; Tian CS; Li XY; Yao YY; Xie P
المصدر:
Journal of Asian natural products research [J Asian Nat Prod Res] 2014; Vol. 16 (6), pp. 629-39. Date of Electronic Publication: 2014 Jun 09.
نوع النشر :
Journal Article
اللغة:
English

معلومة اضافية
- المصدر:
  Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE
- بيانات النشر:
  Publication: London : Informa Healthcare
  Original Publication: [Newark, N.J.?] : Harwood Academic Publishers,
- الموضوع:
  Sesquiterpenes, Guaiane/*chemical synthesis; Cyclization ; Humans ; Molecular Structure ; Phyllanthus/chemistry ; Sesquiterpenes, Guaiane/chemistry ; Stereoisomerism ; Structure-Activity Relationship
- نبذة مختصرة :
  Racemic 4-demethylenglerin A (1'), a simplified analog of the guaiane-type sesquiterpene englerin A (1), has been synthesized. The cyclic hydrocarbon core structure was built through modified Metz approach using epoxynitrile cyclization and direct Aldol reaction to prepare the precursor of RCM. The primary cytotoxicity test summarized that C4 methyl has marked impacts on the bioactivity.
- Contributed Indexing:
  Keywords: 4-demethylenglerin A; epoxynitrile cyclization; total synthesis
- الرقم المعرف:
  0 (4-demethylenglerin A)
  0 (Sesquiterpenes, Guaiane)
  0 (englerin A)
- الموضوع:
  Date Created: 20140610 Date Completed: 20140929 Latest Revision: 20140731
- الموضوع:
  20231215
- الرقم المعرف:
  10.1080/10286020.2014.918111
- الرقم المعرف:
  24911263

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Total synthesis of (+/-)-4-demethylenglerin A.

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