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In utero sensitization modulates IgG isotype, IFN-γ and IL-10 responses of neonates in bancroftian filariasis.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Wiley Country of Publication: England NLM ID: 7910948 Publication Model: Print Cited Medium: Internet ISSN: 1365-3024 (Electronic) Linking ISSN: 01419838 NLM ISO Abbreviation: Parasite Immunol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Oxford, Wiley
    • الموضوع:
      Antibodies, Helminth/*blood ; Filariasis/*immunology ; Immunoglobulin G/*blood ; Infant, Newborn/*immunology ; Interferon-gamma/*immunology ; Interleukin-10/*immunology; Adolescent ; Adult ; Animals ; Child ; Child, Preschool ; Elephantiasis, Filarial ; Female ; Fetal Blood/immunology ; Filariasis/parasitology ; Humans ; Immune Tolerance ; Immunity, Maternally-Acquired ; Infant ; Male ; Middle Aged ; Wuchereria bancrofti/immunology ; Young Adult
    • نبذة مختصرة :
      In utero exposure has been considered as a risk factor for filarial infection. To evaluate the influence of maternal infection on filarial-specific IgG subclass response in neonates and their correlation with plasma levels IL-10 and interferon-γ, 145 pairs of mothers and their respective cord bloods were examined. Transplacental transfer of circulating filarial antigen (CFA) was observed in 34·8% cord bloods from CFA positive mothers. Filarial-specific IgG1, IgG2 and IgG4 responses of cord bloods were found to be positively correlated with CFA of mothers. In contrast, IgG3 responses negatively correlated with CFA of mothers. The % of similarity of recognition pattern in the cord blood with maternal blood was high for IgG3 response than IgG4 in all three groups. An increased levels of IL-10 and decreased levels of interferon gamma (IFN-γ) were observed in cord blood of infected mothers. Interferon gamma was positively correlated with IgG3 and negatively correlated with IgG4 level. On the other hand, IL-10 was positively correlated with IgG4 and CFA, indicating that cytokines may play a role in modulating the immune responses in cord bloods of sensitized foetus. The findings of the study reveal that in utero tolerance or sensitization may influence the filarial-specific immunity to infection in neonates.
      (© 2014 John Wiley & Sons Ltd.)
    • Contributed Indexing:
      Keywords: IgG3; IgG4; circulating filarial antigen; filariasis; interferon gamma; maternal filarial infection
    • الرقم المعرف:
      0 (Antibodies, Helminth)
      0 (Immunoglobulin G)
      130068-27-8 (Interleukin-10)
      82115-62-6 (Interferon-gamma)
    • الموضوع:
      Date Created: 20140607 Date Completed: 20141128 Latest Revision: 20181202
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1111/pim.12121
    • الرقم المعرف:
      24902619