Dezocine pretreatment prevents myoclonus induced by etomidate: a randomized, double-blinded controlled trial.

Publisher: Springer International for the Japan Society of Anesthesiology Country of Publication: Japan NLM ID: 8905667 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-8359 (Electronic) Linking ISSN: 09138668 NLM ISO Abbreviation: J Anesth Subsets: MEDLINE

Publication: Tokyo : Springer International for the Japan Society of Anesthesiology
Original Publication: [Tokyo] : Japan Society of Anesthesiology, [1987-

Analgesics, Opioid/*therapeutic use ; Bridged Bicyclo Compounds, Heterocyclic/*therapeutic use ; Etomidate/*adverse effects ; Hypnotics and Sedatives/*adverse effects ; Intraoperative Complications/*chemically induced ; Intraoperative Complications/*prevention & control ; Myoclonus/*chemically induced ; Myoclonus/*prevention & control ; Tetrahydronaphthalenes/*therapeutic use; Adult ; Aged ; Analgesics, Opioid/adverse effects ; Anesthesia, General ; Bridged Bicyclo Compounds, Heterocyclic/adverse effects ; Double-Blind Method ; Female ; Humans ; Incidence ; Infusions, Intravenous ; Male ; Middle Aged ; Tetrahydronaphthalenes/adverse effects ; Young Adult

The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effects of dezocine on the incidence and severity of myoclonus induced by etomidate. Patients (108) were randomly assigned to one of two groups to receive either 0.1 mg kg(-1) of dezocine (n = 54; Group D) or saline (n = 54; Group S) intravenously 1 min before 0.3 mg kg(-1) etomidate was given. The occurrence and severity (observational score of 0-3) of myoclonus was assessed for 2 min after administration of etomidate. The incidence and the intensity of myoclonus were significantly lower in Group D (0 %) than in Group S (75.9 %) (P < 0.01), and all patients showed stable cardiovascular profiles. The results suggest that infusion of 0.1 mg kg(-1) dezocine 1 min before etomidate administration is effective for suppressing myoclonus induced by etomidate during induction of general anesthesia without significant side-effects.

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0 (Analgesics, Opioid)
0 (Bridged Bicyclo Compounds, Heterocyclic)
0 (Hypnotics and Sedatives)
0 (Tetrahydronaphthalenes)
VHX8K5SV4X (dezocine)
Z22628B598 (Etomidate)

Date Created: 20140527 Date Completed: 20150724 Latest Revision: 20220318

20250114

10.1007/s00540-014-1854-2

24858231