Transdiagnostic dimensions of anxiety and depression moderate motivation-related brain networks during goal maintenance.

Publisher: Wiley Country of Publication: United States NLM ID: 9708816 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6394 (Electronic) Linking ISSN: 10914269 NLM ISO Abbreviation: Depress Anxiety Subsets: MEDLINE

Original Publication: New York, NY : Wiley, c1997-

Amygdala/*physiopathology ; Anxiety/*physiopathology ; Depression/*physiopathology ; Motivation/*physiology ; Neural Pathways/*physiopathology ; Prefrontal Cortex/*physiopathology; Adolescent ; Adult ; Anxiety/psychology ; Brain/physiopathology ; Brain Mapping ; Case-Control Studies ; Depression/psychology ; Female ; Functional Neuroimaging ; Goals ; Humans ; Magnetic Resonance Imaging ; Male ; Stroop Test ; Young Adult

Background: Advancing research on the etiology, prevention, and treatment of psychopathology requires the field to move beyond modular conceptualizations of neural dysfunction toward understanding disturbance in key brain networks. Although some studies of anxiety and depression have begun doing so, they typically suffer from several drawbacks, including: (1) a categorical approach ignoring transdiagnostic processes, (2) failure to account for substantial anxiety and depression comorbidity, (3) examination of networks at rest, which overlooks disruption manifesting only when networks are challenged. Accordingly, the present study examined relationships between transdiagnostic dimensions of anxiety/depression and patterns of functional connectivity while goal maintenance was challenged.
Methods: Participants (n = 179, unselected community members and undergraduates selected to be high/low on anxiety/depression) performed a task in which goal maintenance was challenged (color-word Stroop) while fMRI data were collected. Analyses examined moderation by anxiety/depression of condition-dependent coupling between regions of dorsolateral prefrontal cortex (dlPFC) previously associated with approach and avoidance motivation and amygdala/orbitofrontal cortex (OFC).
Results: Anxious arousal was positively associated with amygdala↔right dlPFC coupling. Depression was positively associated with OFC↔right dlPFC coupling and negatively associated with OFC↔left dlPFC coupling.
Conclusions: Findings advance the field toward an integrative model of the neural instantiation of anxiety/depression by identifying specific, distinct dysfunctions associated with anxiety and depression in networks important for maintaining approach and avoidance goals. Specifically, findings shed light on potential neural mechanisms involved in attentional biases in anxiety and valuation biases in depression and underscore the importance of examining transdiagnostic dimensions of anxiety/depression while networks are challenged.
(© 2014 Wiley Periodicals, Inc.)

Front Syst Neurosci. 2010 Sep 20;4:. (PMID: 20941370)
Cogn Affect Behav Neurosci. 2012 Jun;12(2):308-22. (PMID: 22460723)
Psychol Med. 2008 Apr;38(4):543-54. (PMID: 17803835)
Behav Res Ther. 2007 Feb;45(2):301-11. (PMID: 16677599)
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1942-7. (PMID: 19171889)
Psychophysiology. 2010 May 1;47(3):442-54. (PMID: 20070577)
Biol Psychiatry. 2006 Mar 1;59(5):424-9. (PMID: 16256956)
Psychophysiology. 2012 Sep;49(9):1200-14. (PMID: 22845892)
Nat Rev Neurosci. 2010 Nov;11(11):773-83. (PMID: 20959860)
Behav Res Ther. 2005 Dec;43(12):1577-85. (PMID: 16239152)
Front Integr Neurosci. 2013 Jan 30;7:2. (PMID: 23386814)
Psychiatry Res. 2010 Sep 30;179(2):176-80. (PMID: 20478624)
Arch Gen Psychiatry. 2005 Mar;62(3):273-81. (PMID: 15753240)
Behav Res Ther. 1990;28(6):487-95. (PMID: 2076086)
Biol Psychol. 2006 May;72(2):198-207. (PMID: 16316717)
Biol Psychiatry. 2010 Jan 15;67(2):161-7. (PMID: 19811772)
Arch Gen Psychiatry. 2005 Aug;62(8):922-33. (PMID: 16061770)
Biol Psychiatry. 2009 Dec 15;66(12):1072-4. (PMID: 19944792)
Trends Cogn Sci. 2011 Oct;15(10):483-506. (PMID: 21908230)
Am J Psychiatry. 1986 Jan;143(1):40-4. (PMID: 3942285)
J Psychiatr Res. 2007 Sep;41(6):511-22. (PMID: 17010993)
Biol Psychiatry. 2007 Jan 15;61(2):198-209. (PMID: 17027931)
Psychiatry Res. 2010 Jun 30;182(3):200-6. (PMID: 20488680)
J Abnorm Psychol. 2011 May;120(2):272-85. (PMID: 21553941)
Clin Psychol Rev. 2010 Mar;30(2):203-16. (PMID: 20005616)
Front Hum Neurosci. 2013 Jun 13;7:271. (PMID: 23781192)
Ann N Y Acad Sci. 2007 May;1104:89-107. (PMID: 17416923)
Arch Gen Psychiatry. 2002 Nov;59(11):1027-34. (PMID: 12418936)
Am J Psychiatry. 1995 Mar;152(3):352-7. (PMID: 7864259)
BMC Med. 2013 May 14;11:126. (PMID: 23672542)
Dialogues Clin Neurosci. 2012 Mar;14(1):29-37. (PMID: 22577302)
Psychiatry Res. 2008 Jan 15;162(1):59-72. (PMID: 18093809)
Brain Behav. 2013 Sep;3(5):532-51. (PMID: 24392275)
J Abnorm Psychol. 1996 Aug;105(3):433-9. (PMID: 8772013)
Neuroimage. 2012 Aug 15;62(2):782-90. (PMID: 21979382)
Annu Rev Psychol. 1998;49:377-412. (PMID: 9496627)
Neurosci Biobehav Rev. 2012 Nov;36(10):2232-47. (PMID: 22921284)
J Behav Ther Exp Psychiatry. 1988 Mar;19(1):21-6. (PMID: 3392220)
J Affect Disord. 2012 Jun;139(1):56-65. (PMID: 22425432)
Arch Gen Psychiatry. 2005 Jun;62(6):593-602. (PMID: 15939837)
J Clin Psychiatry. 2008 Mar;69(3):412-7. (PMID: 18348596)
Arch Gen Psychiatry. 2009 Dec;66(12):1361-72. (PMID: 19996041)
Hum Brain Mapp. 2008 Jun;29(6):683-95. (PMID: 17598168)
Psychol Psychother. 2007 Sep;80(Pt 3):443-53. (PMID: 17877867)
Neuroreport. 2001 Dec 21;12(18):3953-7. (PMID: 11742218)
Clin Psychol Rev. 2011 Nov;31(7):1156-68. (PMID: 21855826)
Neuroimage. 2011 Jun 1;56(3):881-9. (PMID: 21356318)
Neuroimage. 2010 Apr 15;50(3):1292-302. (PMID: 20035885)
Psychol Bull. 2007 Jan;133(1):1-24. (PMID: 17201568)
Ann N Y Acad Sci. 2007 Dec;1121:254-72. (PMID: 17872386)
Nat Rev Neurosci. 2013 Nov;14(11):810-4. (PMID: 24135697)
Nature. 1999 Nov 18;402(6759):294-6. (PMID: 10580500)
Neurosci Lett. 2002 Aug 16;328(3):233-6. (PMID: 12147314)
Acta Psychiatr Scand. 2010 Jan;121(1):33-40. (PMID: 19426163)
J Abnorm Psychol. 1995 Feb;104(1):15-25. (PMID: 7897037)
Neuroimage. 2011 Jan 1;54(1):661-70. (PMID: 20728552)
Cogn Affect Behav Neurosci. 2010 Mar;10(1):141-56. (PMID: 20233962)
Am J Psychiatry. 1999 Dec;156(12):1915-23. (PMID: 10588405)
Annu Rev Clin Psychol. 2013;9:177-213. (PMID: 23297790)
Int Clin Psychopharmacol. 2000 Nov;15(6):319-28. (PMID: 11110007)
Ann N Y Acad Sci. 2011 Apr;1224:109-125. (PMID: 21251014)
PLoS One. 2013 Sep 10;8(9):e75058. (PMID: 24040385)
Front Hum Neurosci. 2013 Jun 17;7:284. (PMID: 23785328)

R01 MH061358 United States MH NIMH NIH HHS

Keywords: amygdale; anxiety; depression; dorsolateral prefrontal cortex; orbitofrontal cortex, network; transdiagnostic

Date Created: 20140423 Date Completed: 20150617 Latest Revision: 20220321

20231215

PMC4418555

10.1002/da.22271

24753242