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High resolution imaging beyond the acoustic diffraction limit in deep tissue via ultrasound-switchable NIR fluorescence.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Fluorescent Dyes/*chemistry ; Muscles/*diagnostic imaging ; Optical Imaging/*methods; Animals ; Contrast Media ; Fluorescence ; Infrared Rays ; Nanoparticles ; Swine ; Ultrasonography
    • نبذة مختصرة :
      Fluorescence imaging in deep tissue with high spatial resolution is highly desirable because it can provide details about tissue's structural, functional, and molecular information. Unfortunately, current fluorescence imaging techniques are limited either in penetration depth (microscopy) or spatial resolution (diffuse light based imaging) as a result of strong light scattering in deep tissue. To overcome this limitation, we developed an ultrasound-switchable fluorescence (USF) imaging technique whereby ultrasound was used to switch on/off the emission of near infrared (NIR) fluorophores. We synthesized and characterized unique NIR USF contrast agents. The excellent switching properties of these agents, combined with the sensitive USF imaging system developed in this study, enabled us to image fluorescent targets in deep tissue with spatial resolution beyond the acoustic diffraction limit.
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    • Grant Information:
      R15 EB012312 United States EB NIBIB NIH HHS; 7R15EB012312-02 United States EB NIBIB NIH HHS
    • الرقم المعرف:
      0 (Contrast Media)
      0 (Fluorescent Dyes)
    • الموضوع:
      Date Created: 20140416 Date Completed: 20141118 Latest Revision: 20211021
    • الموضوع:
      20240829
    • الرقم المعرف:
      PMC4003820
    • الرقم المعرف:
      10.1038/srep04690
    • الرقم المعرف:
      24732947