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Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes.

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  • معلومة اضافية
    • المصدر:
      Publisher: Hindawi Limited Country of Publication: England NLM ID: 101605237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6753 (Electronic) NLM ISO Abbreviation: J Diabetes Res Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2019>-: London, United Kingdom : Hindawi Limited
      Original Publication: Nasr City, Cairo : Hindawi Publishing Corporation, [2013]-
    • الموضوع:
      Diabetes Mellitus, Type 2/*complications ; Diabetic Neuropathies/*complications ; Methylmalonic Acid/*urine ; Polyneuropathies/*complications ; Vitamin B 12 Deficiency/*complications; Adult ; Aged ; Asian People ; Biomarkers/blood ; Biomarkers/urine ; China ; Diabetic Neuropathies/blood ; Diabetic Neuropathies/physiopathology ; Diabetic Neuropathies/urine ; Female ; Humans ; Male ; Methylmalonic Acid/blood ; Middle Aged ; Motor Neurons/metabolism ; Neural Conduction ; Polyneuropathies/blood ; Polyneuropathies/physiopathology ; Polyneuropathies/urine ; Prospective Studies ; Sensory Receptor Cells/metabolism ; Severity of Illness Index ; Vitamin B 12/blood
    • نبذة مختصرة :
      The rising incidence of diabetes and its negative impact on quality of life highlights the urgent need to develop biomarkers of early nerve damage. Measurement of total vitamin B12 has some limitations. We want to determine the levels of urinary methylmalonic acid and its relationships with serum vitamin B12 and polyneuropathy. The 176 Chinese patients with Type 2 diabetes mellitus were divided into 3 groups according to the levels of vitamin B12. A gas chromatography mass spectrometric technique was used to determine blood methylmalonic acid and urinary methylmalonic acid. The diagnosis of distal diabetic polyneuropathy was based on the determination of bilateral limb sensory and motor nerve conduction velocity and amplitude with electromyogram. Multiple regression analysis revealed that urinary methylmalonic acid/creatinine, blood methylmalonic acid, and so forth were variables that influenced diabetic polyneuropathy significantly. Nerve sensory conduction velocity and nerve amplitude in the group of urinary methylmalonic acid/creatinine >3.5 mmol/mol decreased significantly. Superficial peroneal nerve sensory and motor conduction velocity and ulnar nerve compound motor active potential amplitude were inversely correlated with urinary methylmalonic acid/creatinine. Urinary methylmalonic acid correlates with serum vitamin B12 levels in person with diabetes and is a sensitive marker of early polyneuropathy.
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    • الرقم المعرف:
      0 (Biomarkers)
      8LL8S712J7 (Methylmalonic Acid)
      P6YC3EG204 (Vitamin B 12)
    • الموضوع:
      Date Created: 20140411 Date Completed: 20141028 Latest Revision: 20221207
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC3955587
    • الرقم المعرف:
      10.1155/2014/921616
    • الرقم المعرف:
      24719898