Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

DNA Damage*; Antineoplastic Agents/*adverse effects ; Cell Cycle Checkpoints/*drug effects ; Cell Proliferation/*drug effects ; Mitosis/*drug effects ; Neoplasms/*drug therapy; Adaptation, Physiological/genetics ; Antineoplastic Agents/therapeutic use ; Cell Cycle Checkpoints/genetics ; DNA Repair ; Genomic Instability/drug effects ; Genomic Instability/genetics ; Humans ; Mitosis/genetics ; Neoplasms/genetics ; Neoplasms/pathology

When a human cell detects damaged DNA, it initiates the DNA damage response (DDR) that permits it to repair the damage and avoid transmitting it to daughter cells. Despite this response, changes to the genome occur and some cells, such as proliferating cancer cells, are prone to genome instability. The cellular processes that lead to genomic changes after a genotoxic event are not well understood. Our research focuses on the relationship between genotoxic cancer drugs and checkpoint adaptation, which is the process of mitosis with damaged DNA. We examine the types of DNA damage induced by widely used cancer drugs and describe their effects upon proliferating cancer cells. There is evidence that cell death caused by genotoxic cancer drugs in some cases includes exiting a DNA damage cell cycle arrest and entry into mitosis. Furthermore, some cells are able to survive this process at a time when the genome is most susceptible to change or rearrangement. Checkpoint adaptation is poorly characterised in human cells; we predict that increasing our understanding of this pathway may help to understand genomic instability in cancer cells and provide insight into methods to improve the efficacy of current cancer therapies.

Biochim Biophys Acta. 1980 Jun 27;608(1):174-81. (PMID: 6892995)
Cancer Res. 2006 Nov 1;66(21):10253-7. (PMID: 17079442)
Int J Radiat Biol. 1997 Oct;72(4):409-21. (PMID: 9343106)
Cancer Res. 1993 Nov 15;53(22):5462-9. (PMID: 7693342)
Curr Med Chem Anticancer Agents. 2005 Jul;5(4):363-72. (PMID: 16101488)
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4827-32. (PMID: 8643488)
Mol Cell. 2003 Mar;11(3):827-35. (PMID: 12667463)
J Biol Chem. 2001 May 25;276(21):17914-9. (PMID: 11279124)
Cell. 1993 Nov 19;75(4):729-39. (PMID: 8242745)
Nat Rev Cancer. 2006 Oct;6(10):789-802. (PMID: 16990856)
Mol Cell. 2004 Feb 13;13(3):307-16. (PMID: 14967139)
Crit Rev Oncol Hematol. 2005 Mar;53(3):241-52. (PMID: 15718149)
Toxicol Sci. 2011 Mar;120 Suppl 1:S130-45. (PMID: 21163908)
Curr Biol. 2002 Jan 8;12(1):73-7. (PMID: 11790307)
Cancer Lett. 2005 Jan 20;217(2):129-38. (PMID: 15617830)
Cell. 2011 Mar 4;144(5):646-74. (PMID: 21376230)
Science. 2007 May 25;316(5828):1160-6. (PMID: 17525332)
Br J Cancer. 1999 Jul;80(10):1599-607. (PMID: 10408406)
J Biol Chem. 2003 Aug 8;278(32):30057-62. (PMID: 12766152)
Chem Biol. 2013 May 23;20(5):648-59. (PMID: 23706631)
J Clin Oncol. 1999 Feb;17(2):569-77. (PMID: 10080601)
Cell. 2004 May 28;117(5):555-6. (PMID: 15163402)
Oncogene. 2004 Apr 12;23(16):2825-37. (PMID: 15077146)
Trends Biochem Sci. 1995 Oct;20(10):435-9. (PMID: 8533159)
Cell Death Differ. 2002 Dec;9(12):1287-93. (PMID: 12478465)
Oncogene. 2013 Sep 26;32(39):4593-601. (PMID: 23318447)
Trends Biochem Sci. 2011 Mar;36(3):133-40. (PMID: 20947357)
Nat Genet. 2001 Mar;27(3):247-54. (PMID: 11242102)
Curr Drug Targets. 2010 Mar;11(3):279-90. (PMID: 20210753)
Cancer Res. 2004 Sep 15;64(18):6635-44. (PMID: 15374978)
Clin Cancer Res. 1995 Jul;1(7):723-30. (PMID: 9816038)
Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19701-6. (PMID: 17179038)
Carcinogenesis. 1983;4(2):199-205. (PMID: 6825208)
Radiother Oncol. 1998 Oct;49(1):61-5. (PMID: 9886699)
Mol Cancer Ther. 2007 Apr;6(4):1406-13. (PMID: 17431119)
Am J Surg. 1963 May;105:574-8. (PMID: 13947966)
Nature. 2004 Nov 18;432(7015):316-23. (PMID: 15549093)
Cancer Treat Rev. 1997 Jan;23(1):35-61. (PMID: 9189180)
Int J Radiat Oncol Biol Phys. 2005 Mar 1;61(3):915-21. (PMID: 15708275)
EMBO J. 2005 Oct 5;24(19):3411-22. (PMID: 16163388)
Cancer Res. 1984 Apr;44(4):1693-7. (PMID: 6367971)
Trends Biochem Sci. 2011 May;36(5):262-71. (PMID: 21353781)
Cancer Res. 1984 Jan;44(1):379-82. (PMID: 6690051)
Mol Cell. 2002 Aug;10(2):373-85. (PMID: 12191482)
Curr Opin Chem Biol. 1999 Feb;3(1):77-83. (PMID: 10021401)
Science. 2003 Jun 6;300(5625):1542-8. (PMID: 12791985)
J Clin Oncol. 1999 Jan;17(1):409-22. (PMID: 10458260)
Nature. 2003 Jan 30;421(6922):499-506. (PMID: 12556884)
Cell. 2004 May 28;117(5):575-88. (PMID: 15163406)
Mutat Res. 2005 Mar;589(2):111-35. (PMID: 15795165)
Cancer Res. 2001 Feb 1;61(3):1029-37. (PMID: 11221829)
Genes Dev. 2000 Jun 15;14(12):1448-59. (PMID: 10859164)
Cell. 2006 Mar 10;124(5):943-55. (PMID: 16530042)
J Biol Chem. 1995 Sep 15;270(37):21429-32. (PMID: 7665550)
J Nucleic Acids. 2010 Nov 21;2010:543531. (PMID: 21113301)
Nat Cell Biol. 2006 Jan;8(1):37-45. (PMID: 16327781)
Cancer Treat Rev. 2008 Dec;34(8):737-49. (PMID: 18722718)
Nat Rev Cancer. 2002 Mar;2(3):188-200. (PMID: 11990855)
Drug Discov Today. 2012 Mar;17(5-6):194-202. (PMID: 22192883)
Oncogene. 2008 Oct 2;27(44):5797-807. (PMID: 18574471)
Nucleic Acids Res. 2012 Oct;40(18):e143. (PMID: 22730301)
J Neurooncol. 2012 Apr;107(2):359-64. (PMID: 22045118)
Int J Radiat Oncol Biol Phys. 1995 Nov 1;33(4):781-96. (PMID: 7591884)
Nat Rev Cancer. 2009 May;9(5):338-50. (PMID: 19377506)
J Biol Chem. 2006 Apr 7;281(14):9346-50. (PMID: 16431910)
Life Sci. 2011 Aug 15;89(7-8):259-68. (PMID: 21736880)
J Clin Oncol. 1999 Aug;17(8):2604-13. (PMID: 10561328)
Drug Resist Updat. 2001 Oct;4(5):303-13. (PMID: 11991684)
Chem Rev. 2006 Feb;106(2):277-301. (PMID: 16464006)
Adv Cancer Res. 2010;108:73-112. (PMID: 21034966)
Curr Opin Cell Biol. 2007 Apr;19(2):238-45. (PMID: 17303408)
J Clin Invest. 2006 Jan;116(1):80-9. (PMID: 16357944)
Genes Dev. 2002 Jan 15;16(2):198-208. (PMID: 11799063)
J Biol Chem. 1985 Nov 25;260(27):14873-8. (PMID: 2997227)
Oral Oncol. 2001 Apr;37(3):288-95. (PMID: 11287284)
Nature. 2009 Oct 22;461(7267):1071-8. (PMID: 19847258)
Cancer Res. 1996 Sep 1;56(17):4006-12. (PMID: 8752171)
Cancer Res. 2001 Aug 1;61(15):5843-9. (PMID: 11479224)
Nature. 1962 Jun 2;194:882-3. (PMID: 13860354)
J Cell Sci. 2000 Nov;113 ( Pt 22):3889-96. (PMID: 11058076)
Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20720-5. (PMID: 21076032)
Genes Dev. 2007 Dec 15;21(24):3342-55. (PMID: 18079180)
Cancer Biol Ther. 2013 May;14(5):379-89. (PMID: 23380594)
Cancer Cell. 2008 Aug 12;14(2):111-22. (PMID: 18656424)
Mutat Res. 1997 Jan 3;373(1):125-37. (PMID: 9015161)
Science. 2005 Apr 22;308(5721):551-4. (PMID: 15790808)
Nat Rev Cancer. 2004 Sep;4(9):737-47. (PMID: 15343280)
Biochem J. 2012 Sep 15;446(3):373-81. (PMID: 22686412)
Int J Radiat Oncol Biol Phys. 1991 May 15;21(1):109-22. (PMID: 2032882)
Nat Rev Cancer. 2005 Jan;5(1):65-72. (PMID: 15630416)
Nature. 2000 Nov 23;408(6811):433-9. (PMID: 11100718)
Nat Rev Cancer. 2008 Mar;8(3):193-204. (PMID: 18256616)
J Neurosurg. 1985 Nov;63(5):726-32. (PMID: 4056874)
Cancer Lett. 2010 Mar 28;289(2):178-87. (PMID: 19758748)
Mol Cell Biol. 2005 Apr;25(7):2853-60. (PMID: 15767688)
Free Radic Res. 2012 Apr;46(4):382-419. (PMID: 22276778)
IUBMB Life. 2012 Feb;64(2):169-79. (PMID: 22162200)
Cancer Res. 1989 Sep 15;49(18):5077-82. (PMID: 2548710)
DNA Repair (Amst). 2004 Nov 2;3(11):1389-407. (PMID: 15380096)
Nat Rev Cancer. 2012 Jan 12;12(2):104-20. (PMID: 22237395)
Mol Cell Biol. 2001 Jul;21(13):4129-39. (PMID: 11390642)
Nature. 1999 Oct 7;401(6753):616-20. (PMID: 10524633)
Biochemistry. 2002 Mar 5;41(9):3109-18. (PMID: 11863450)
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13827-32. (PMID: 14605214)
Mol Pharmacol. 2009 Jul;76(1):208-14. (PMID: 19403702)
Br J Cancer. 2008 Feb 12;98(3):523-8. (PMID: 18231106)
J Nucleic Acids. 2010 Dec 16;2010:592980. (PMID: 21209706)
Prog Cell Cycle Res. 2003;5:453-9. (PMID: 14593740)
J Cancer Res Ther. 2005 Jul-Sep;1(3):187-90. (PMID: 17998651)
Cell. 1997 Sep 19;90(6):1097-106. (PMID: 9323137)
Nat Rev Cancer. 2007 Aug;7(8):573-84. (PMID: 17625587)
Nat Rev Cancer. 2003 May;3(5):330-8. (PMID: 12724731)
Mol Cell. 2006 May 19;22(4):501-10. (PMID: 16713580)
Eur J Cancer. 2002 Jul;38(10):1348-50. (PMID: 12091065)
Cancer Treat Rep. 1984 Mar;68(3):505-13. (PMID: 6538459)
Cancer Res. 1999 Aug 1;59(15):3761-7. (PMID: 10446993)
Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10422-6. (PMID: 7479797)
Nat Protoc. 2006;1(1):23-9. (PMID: 17406208)
FEBS Lett. 2013 Sep 17;587(18):3089-95. (PMID: 23954627)
Cancer Res. 2004 Dec 15;64(24):9035-40. (PMID: 15604269)
Genes Dev. 2007 Jun 15;21(12):1472-7. (PMID: 17575048)
Nat Genet. 2013 Oct;45(10):1113-20. (PMID: 24071849)
Nature. 2012 Jul 18;487(7407):330-7. (PMID: 22810696)
Cell Death Differ. 2008 Jul;15(7):1153-62. (PMID: 18404154)
Nature. 2001 May 17;411(6835):366-74. (PMID: 11357144)
Nat Cell Biol. 2003 Feb;5(2):161-5. (PMID: 12545175)
J Biol Chem. 1984 Nov 10;259(21):13560-6. (PMID: 6092381)
DNA Repair (Amst). 2009 Sep 2;8(9):1101-9. (PMID: 19464963)
Mutagenesis. 2011 Jan;26(1):125-32. (PMID: 21164193)
Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1394-7. (PMID: 1996340)
DNA Repair (Amst). 2012 Nov 1;11(11):864-73. (PMID: 23058634)
Nature. 1969 Apr 26;222(5191):385-6. (PMID: 5782119)
Chromosoma. 1997 Nov;106(6):348-60. (PMID: 9362543)
Mutat Res. 1998 Jun 5;401(1-2):153-64. (PMID: 9639696)
Leukemia. 2010 Apr;24(4):679-86. (PMID: 20130602)
Mol Pharmacol. 2001 Dec;60(6):1383-91. (PMID: 11723246)
Br J Ophthalmol. 1937 Jun;21(6):273-98. (PMID: 18169450)
Cancer Treat Rep. 1987 Dec;71(12):1231-7. (PMID: 3319135)
Clin Cancer Res. 2000 Apr;6(4):1205-18. (PMID: 10778943)
Science. 2001 Nov 23;294(5547):1713-6. (PMID: 11721054)
Free Radic Biol Med. 2002 Oct 1;33(7):886-93. (PMID: 12361800)
Nat Rev Mol Cell Biol. 2011 Jun;12(6):385-92. (PMID: 21527953)
Cell Growth Differ. 1994 Sep;5(9):983-93. (PMID: 7819136)
J Med Res. 1919 Sep;40(3):497-508.3. (PMID: 19972497)
Biochemistry. 2002 Aug 6;41(31):9911-20. (PMID: 12146956)
DNA Repair (Amst). 2004 Aug-Sep;3(8-9):889-900. (PMID: 15279774)
CA Cancer J Clin. 2005 Mar-Apr;55(2):117-34. (PMID: 15761080)
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3578-82. (PMID: 9520408)
J Biol Chem. 2008 Jul 11;283(28):19322-8. (PMID: 18480045)
Oncogene. 2005 Jul 14;24(30):4765-77. (PMID: 15870702)
Cell Death Differ. 2009 Jan;16(1):3-11. (PMID: 18846107)
Cancer Chemother Pharmacol. 1995;37(1-2):161-7. (PMID: 7497587)
Clin Cancer Res. 1999 Jun;5(6):1347-52. (PMID: 10389918)
J Biol Chem. 1987 Jun 15;262(17):8235-41. (PMID: 2954951)
J Biol Chem. 1998 Mar 6;273(10):5858-68. (PMID: 9488723)
Curr Neurol Neurosci Rep. 2005 May;5(3):198-206. (PMID: 15865885)
Cell Death Differ. 2008 Mar;15(3):555-66. (PMID: 18064041)
Nat Rev Cancer. 2011 Apr;11(4):239-53. (PMID: 21430696)
J Anal Toxicol. 2004 Mar;28(2):138-40. (PMID: 15068570)
Radiother Oncol. 1995 Aug;36(2):128-32. (PMID: 7501810)
EMBO J. 2004 Jul 7;23(13):2674-83. (PMID: 15201865)
Cell. 2000 Mar 17;100(6):681-92. (PMID: 10761933)
Radiat Res. 2011 Jun;175(6):708-18. (PMID: 21438660)
FASEB J. 2003 Jul;17(10):1195-214. (PMID: 12832285)
Mol Cell. 2001 Feb;7(2):293-300. (PMID: 11239458)
Nature. 1993 Apr 22;362(6422):709-15. (PMID: 8469282)
Int J Med Sci. 2012;9(3):193-9. (PMID: 22408567)
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14116-21. (PMID: 20660785)

0 (Antineoplastic Agents)

Date Created: 20140228 Date Completed: 20150213 Latest Revision: 20211021

20221213

PMC3975345

10.3390/ijms15033403

24573252