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A bioartificial renal tubule device embedding human renal stem/progenitor cells.

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  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science
    • الموضوع:
      Bioartificial Organs* ; Equipment and Supplies*; Kidney Tubules, Proximal/*physiology ; Regeneration/*physiology ; Stem Cells/*physiology; Cell Differentiation/physiology ; Cell Line ; Humans ; Kidney Tubules, Proximal/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Stem Cells/metabolism
    • نبذة مختصرة :
      We present a bio-inspired renal microdevice that resembles the in vivo structure of a kidney proximal tubule. For the first time, a population of tubular adult renal stem/progenitor cells (ARPCs) was embedded into a microsystem to create a bioengineered renal tubule. These cells have both multipotent differentiation abilities and an extraordinary capacity for injured renal cell regeneration. Therefore, ARPCs may be considered a promising tool for promoting regenerative processes in the kidney to treat acute and chronic renal injury. Here ARPCs were grown to confluence and exposed to a laminar fluid shear stress into the chip, in order to induce a functional cell polarization. Exposing ARPCs to fluid shear stress in the chip led the aquaporin-2 transporter to localize at their apical region and the Na(+)K(+)ATPase pump at their basolateral portion, in contrast to statically cultured ARPCs. A recovery of urea and creatinine of (20±5)% and (13±5)%, respectively, was obtained by the device. The microengineered biochip here-proposed might be an innovative "lab-on-a-chip" platform to investigate in vitro ARPCs behaviour or to test drugs for therapeutic and toxicological responses.
    • Comments:
      Erratum in: PLoS One. 2014; 9(6): e100141.
      Erratum in: PLoS One. 2015 May 08;10(5):e0128261. doi: 10.1371/journal.pone.0128261. (PMID: 25955358)
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    • الرقم المعرف:
      EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
    • الموضوع:
      Date Created: 20140206 Date Completed: 20140908 Latest Revision: 20211021
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC3907467
    • الرقم المعرف:
      10.1371/journal.pone.0087496
    • الرقم المعرف:
      24498117