Uric acid levels predict future blood pressure and new onset hypertension in the general Japanese population.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8811625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5527 (Electronic) Linking ISSN: 09509240 NLM ISO Abbreviation: J Hum Hypertens Subsets: MEDLINE

Publication: <2003->: London : Nature Publishing Group
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical, Macmillan Press, c1987-

Asian People* ; Blood Pressure*/drug effects; Hypertension/*ethnology ; Hyperuricemia/*ethnology ; Uric Acid/*blood; Adult ; Antihypertensive Agents/therapeutic use ; Biomarkers/blood ; Chi-Square Distribution ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Hyperuricemia/blood ; Hyperuricemia/diagnosis ; Incidence ; Japan/epidemiology ; Kaplan-Meier Estimate ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Proportional Hazards Models ; Prospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Up-Regulation

We tested the hypothesis that uric acid levels predict new-onset hypertension in the Japanese general population. Normotensive individuals who visited our hospital for a yearly health checkup (n=8157, men=61.0% and age=50.7±12.2 years) were enrolled in the present study. After baseline evaluation, participants were followed up for a median of 48.3 months (range 4.9-101.0 months), with the endpoint being the development of hypertension, defined as systolic blood pressure (BP) > or = 140 mm Hg, diastolic BP > or = 90 mm Hg or the use of antihypertensive medication. The impact of uric acid and other cardiovascular risk factors at baseline on future BP and development of hypertension was assessed. During follow-up, 19.0% of women (n=605) and 29.5% of men (n=1469) participants developed hypertension. Incident hypertension was increased across the quartiles for baseline uric acid levels (P<0.0001), and multivariate Cox proportional hazards analysis revealed a significant and independent association between the uric acid level and the onset of hypertension in both men and women participants (P<0.05). Furthermore, uric acid was independently and positively correlated with future BP (P<0.05). Thus, uric acid is an independent predictor of new-onset hypertension in both women and men.

Comment in: J Hum Hypertens. 2014 Sep;28(9):519-20. (PMID: 24430708)

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0 (Antihypertensive Agents)
0 (Biomarkers)
268B43MJ25 (Uric Acid)

Date Created: 20140117 Date Completed: 20160509 Latest Revision: 20221207

20221213

10.1038/jhh.2013.143

24430703