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Lowering effect of valsartan on fetuin-A in type 1 diabetes mellitus.

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  • معلومة اضافية
    • المصدر:
      Publisher: Iranian Society of Nephrology Country of Publication: Iran NLM ID: 101316967 Publication Model: Print Cited Medium: Internet ISSN: 1735-8604 (Electronic) Linking ISSN: 17358582 NLM ISO Abbreviation: Iran J Kidney Dis Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Tehran : Iranian Society of Nephrology
    • الموضوع:
      alpha-2-HS-Glycoprotein*/drug effects ; alpha-2-HS-Glycoprotein*/metabolism; Albuminuria/*metabolism ; Angiotensin II Type 1 Receptor Blockers/*pharmacology ; Diabetes Mellitus, Type 1/*metabolism ; Renin-Angiotensin System/*drug effects ; Tetrazoles/*pharmacology ; Valine/*analogs & derivatives; Adult ; Albuminuria/complications ; Cholesterol, LDL/blood ; Creatine/urine ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Female ; Glycated Hemoglobin/metabolism ; Humans ; Male ; Renin-Angiotensin System/physiology ; Valine/pharmacology ; Valsartan ; Young Adult
    • نبذة مختصرة :
      Introduction: Fetuin-A (A2-HS-glycoprotein) is a protein that plays several functions in human physiology and pathophysiology. The role of fetuin-A in type 1 diabetes mellitus (DM) has been less studied. We investigated the serum levels of fetuin-A in type 1 diabetic patients with microalbuminuria. Furthermore, the blocking effect of renin-angiotensin-aldosteron system on serum levels of fetuin-A was assessed.
      Materials and Methods: From January 2010 to May 2011, 32 patients with type 1 DM with confirmed microalbuminuria were included in this study in Isfahan, Iran. Serum fetuin-A levels before and 8 weeks after valsartan administration were measured. In addition, serum lipid profile, creatinine, hemoglobin A1c, and urine microalbuminuria were determined.
      Results: The mean age of participants was 21.65 +/- 0.38 years. Before valsartan administration, the mean values of fetuin-A were not significantly different between males and females (64.22 +/- 1.77 ng/mL versus 61.39 +/- 3.35 ng/mL, respectively). After valsartan administration, serum levels of fetuin-A and urine albumin-creatinine significantly decreased. A negative correlation was observed between serum fetuin-A level after valsartan administration and serum low-density lipoprotein cholesterol level (P = .007, r = -0.507).
      Conclusions: Administration angiotensin receptor blockers concomitantly decreases fetuin-A levels and urine albumin levels.
    • الرقم المعرف:
      0 (Angiotensin II Type 1 Receptor Blockers)
      0 (Cholesterol, LDL)
      0 (Glycated Hemoglobin A)
      0 (Tetrazoles)
      0 (alpha-2-HS-Glycoprotein)
      0 (hemoglobin A1c protein, human)
      80M03YXJ7I (Valsartan)
      HG18B9YRS7 (Valine)
      MU72812GK0 (Creatine)
    • الموضوع:
      Date Created: 20131119 Date Completed: 20140630 Latest Revision: 20221207
    • الموضوع:
      20250114
    • الرقم المعرف:
      24241089