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Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb/c mice.
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- معلومة اضافية
- المصدر:
Publisher: [Oxford University Press Country of Publication: England NLM ID: 8916182 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2377 (Electronic) Linking ISSN: 09538178 NLM ISO Abbreviation: Int Immunol Subsets: MEDLINE
- بيانات النشر:
Original Publication: Oxford : [Oxford University Press, 1989-
- الموضوع:
- نبذة مختصرة :
Zinc oxide nanoparticles (ZNPs) have been used in dietary supplements and may cause an immunomodulatory effect. The present study investigated the effect of ZNPs on antigen-specific immune responses in mice sensitized with the T-cell-dependent antigen ovalbumin (OVA). BALB/c mice were intraperitoneally administered ZNPs (0.25, 0.5, 1 and 3mg) once, in combination with OVA, and the serum antibodies, splenocyte reactivity and activation of antigen-presenting cells were examined. The serum levels of OVA-specific IgG1 and IgE were found significantly enhanced by treatment with ZNPs over control. An increased level of IL-2, IL-4, IL-6, IL-17 and decreased level of IL-10 and TNF-α in splenocytes administered with ZNPs were observed in comparison with control. The ZNPs and OVA-stimulated T lymphocytes showed enhanced proliferation compared with control. Macrophages and B cells showed high expression of MHC class II, whereas higher expression of CD11b in macrophages of the ZNPs and ZNPs/OVA treated groups was observed. The lungs and spleen had increased eosinophils and mast cell numbers. Also, myeloperoxidase activity in lungs was found to be increased by 2.5-fold in the case of ZNPs and 3.75-fold increase in ZNPs/OVA, whereas in intestine, there was significant increase in both the groups. Increased expression of the genes for GATA-3, SOCS-3, TLR-4, IL-13 and IL-5 in the intestine was observed. Collectively, these data indicate that systemic exposure to a single administration of ZNPs could enhance subsequent antigen-specific immune reactions, including the serum production of antigen-specific antibodies, and the functionality of T cells.
- Contributed Indexing:
Keywords: allergy; anaphylaxis; antigen-presenting cells; cytokines; mast cells
- الرقم المعرف:
0 (Adjuvants, Immunologic)
0 (Cytokines)
0 (GATA3 Transcription Factor)
0 (GATA3 protein, human)
0 (Immunoglobulin G)
0 (Socs3 protein, mouse)
0 (Suppressor of Cytokine Signaling 3 Protein)
0 (Suppressor of Cytokine Signaling Proteins)
37341-29-0 (Immunoglobulin E)
9006-59-1 (Ovalbumin)
SOI2LOH54Z (Zinc Oxide)
- الموضوع:
Date Created: 20131115 Date Completed: 20141203 Latest Revision: 20161125
- الموضوع:
20240829
- الرقم المعرف:
10.1093/intimm/dxt053
- الرقم المعرف:
24225181
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