A decade after SARS: strategies for controlling emerging coronaviruses.

Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101190261 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-1534 (Electronic) Linking ISSN: 17401526 NLM ISO Abbreviation: Nat Rev Microbiol Subsets: MEDLINE

Original Publication: London, UK : Nature Pub. Group, c2003-

Communicable Diseases, Emerging/*epidemiology ; Communicable Diseases, Emerging/*prevention & control ; Coronavirus/*isolation & purification ; Coronavirus Infections/*epidemiology ; Coronavirus Infections/*prevention & control; Coronavirus/genetics ; Coronavirus/pathogenicity ; Coronavirus/physiology ; Drug Discovery/trends ; Humans ; Receptors, Virus/metabolism ; Viral Tropism ; Viral Vaccines/immunology ; Viral Vaccines/isolation & purification

Two novel coronaviruses have emerged in humans in the twenty-first century: severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), both of which cause acute respiratory distress syndrome (ARDS) and are associated with high mortality rates. There are no clinically approved vaccines or antiviral drugs available for either of these infections; thus, the development of effective therapeutic and preventive strategies that can be readily applied to new emergent strains is a research priority. In this Review, we describe the emergence and identification of novel human coronaviruses over the past 10 years, discuss their key biological features, including tropism and receptor use, and summarize approaches for developing broadly effective vaccines.
Competing Interests: DECLARATION OF COMPETING FINANCIAL INTERESTS The authors have no competing interests as defined by Nature Publishing Group, or other interests that might be perceived to influence the results and discussion reported in this paper.

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U19 AI100625 United States AI NIAID NIH HHS; U54 AI057157 United States AI NIAID NIH HHS

0 (Receptors, Virus)
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Date Created: 20131113 Date Completed: 20140106 Latest Revision: 20231113

20250114

PMC5147543

10.1038/nrmicro3143

24217413