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U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8804070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5640 (Electronic) Linking ISSN: 09543007 NLM ISO Abbreviation: Eur J Clin Nutr Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2003->: London : Nature Publishing Group
      Original Publication: London : J. Libbey, c1988-
    • الموضوع:
      Cardiac Surgical Procedures*; Atrial Fibrillation/*blood ; Atrial Fibrillation/*epidemiology ; Docosahexaenoic Acids/*adverse effects ; Docosahexaenoic Acids/*blood; Adolescent ; Adult ; Australia/epidemiology ; Dietary Supplements ; Docosahexaenoic Acids/administration & dosage ; Eicosapentaenoic Acid/administration & dosage ; Eicosapentaenoic Acid/adverse effects ; Eicosapentaenoic Acid/blood ; Female ; Fish Oils/administration & dosage ; Humans ; Iceland/epidemiology ; Incidence ; Logistic Models ; Male ; Multivariate Analysis ; Odds Ratio ; Postoperative Care ; Randomized Controlled Trials as Topic ; Young Adult
    • نبذة مختصرة :
      Background/objectives: Randomised controlled trials (RCTs) evaluating the effect of fish oil supplementation on postoperative atrial fibrillation (POAF) following cardiac surgery have produced mixed results. In this study, we examined relationships between levels of red blood cell (RBC) n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) and the incidence of POAF.
      Subjects/methods: We used combined data (n=355) from RCTs conducted in Australia and Iceland. The primary end point was defined as POAF lasting >10 min in the first 6 days following surgery. The odds ratios (ORs) for POAF were compared between quintiles of preoperative RBC n-3 LC-PUFA levels by multivariable logistic regression.
      Results: Subjects with RBC docosahexaenoic acid (DHA) in the fourth quintile, comprising a RBC DHA range of 7.0-7.9%, had the lowest incidence of POAF. Subjects in the lowest and highest quintiles had significantly higher risk of developing POAF compared with those in the fourth quintile (OR=2.36: 95% CI; 1.07-5.24 and OR=2.45: 95% CI; 1.16-5.17, respectively). There was no association between RBC eicosapentaenoic acid levels and POAF incidence.
      Conclusions: The results suggest a 'U-shaped' relationship between RBC DHA levels and POAF incidence. The possibility of increased risk of POAF at high levels of DHA suggests an upper limit for n-3 LC-PUFAs in certain conditions.
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    • الرقم المعرف:
      0 (Fish Oils)
      25167-62-8 (Docosahexaenoic Acids)
      AAN7QOV9EA (Eicosapentaenoic Acid)
    • الموضوع:
      Date Created: 20131031 Date Completed: 20140821 Latest Revision: 20211021
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1038/ejcn.2013.215
    • الرقم المعرف:
      24169465