Maize prolamins could induce a gluten-like cellular immune response in some celiac disease patients.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Celiac Disease/*diagnosis ; Celiac Disease/*immunology ; Immunity, Cellular/*drug effects ; Prolamins/*immunology ; Zea mays/*chemistry; Celiac Disease/diet therapy ; Diet, Gluten-Free ; Glutens/adverse effects ; Glutens/immunology ; Humans ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Prolamins/adverse effects ; Triticum/adverse effects ; Triticum/chemistry

Celiac disease (CD) is an autoimmune-mediated enteropathy triggered by dietary gluten in genetically prone individuals. The current treatment for CD is a strict lifelong gluten-free diet. However, in some CD patients following a strict gluten-free diet, the symptoms do not remit. These cases may be refractory CD or due to gluten contamination; however, the lack of response could be related to other dietary ingredients, such as maize, which is one of the most common alternatives to wheat used in the gluten-free diet. In some CD patients, as a rare event, peptides from maize prolamins could induce a celiac-like immune response by similar or alternative pathogenic mechanisms to those used by wheat gluten peptides. This is supported by several shared features between wheat and maize prolamins and by some experimental results. Given that gluten peptides induce an immune response of the intestinal mucosa both in vivo and in vitro, peptides from maize prolamins could also be tested to determine whether they also induce a cellular immune response. Hypothetically, maize prolamins could be harmful for a very limited subgroup of CD patients, especially those that are non-responsive, and if it is confirmed, they should follow, in addition to a gluten-free, a maize-free diet.

J Agric Food Chem. 2009 May 13;57(9):3754-9. (PMID: 19290628)
Annu Rev Immunol. 2011;29:493-525. (PMID: 21219178)
Gastroenterology. 2009 Jul;137(1):88-93. (PMID: 19362553)
Clin Exp Immunol. 2005 Jun;140(3):408-16. (PMID: 15932501)
Hum Immunol. 2012 Oct;73(10):992-7. (PMID: 22836039)
Immunogenetics. 2012 Jun;64(6):455-60. (PMID: 22322673)
Gut. 2013 Jan;62(1):43-52. (PMID: 22345659)
N Engl J Med. 2007 Oct 25;357(17):1731-43. (PMID: 17960014)
Clin Chim Acta. 2005 Jun;356(1-2):134-42. (PMID: 15936309)
Gut. 2007 Jun;56(6):889-90. (PMID: 17519496)
Plant Foods Hum Nutr. 2012 Mar;67(1):24, 30. (PMID: 22298027)
Gut. 2005 Jun;54(6):769-74. (PMID: 15888782)
Gastroenterology. 2008 Jul;135(1):194-204.e3. (PMID: 18485912)
Gut. 2010 Apr;59(4):547-57. (PMID: 20332526)
Dig Liver Dis. 2006 Oct;38(10):784-5. (PMID: 16169780)
World J Gastroenterol. 2012 Mar 28;18(12):1348-56. (PMID: 22493548)
Clin Chim Acta. 1991 Dec 31;204(1-3):109-22. (PMID: 1819454)
Am J Clin Nutr. 2012 Aug;96(2):337-44. (PMID: 22760575)
Am J Gastroenterol. 2012 Jan;107(1):111-7. (PMID: 21946279)
Am J Physiol Gastrointest Liver Physiol. 2002 Oct;283(4):G996-G1003. (PMID: 12223360)
Am J Gastroenterol. 2011 Jul;106(7):1318-24. (PMID: 21364548)
J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):136-60. (PMID: 22197856)
Clin Exp Immunol. 2012 Aug;169(2):129-36. (PMID: 22774987)
J Immunol. 2008 Mar 1;180(5):3268-78. (PMID: 18292551)
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2831-6. (PMID: 17307878)
J Exp Med. 2012 Dec 17;209(13):2395-408. (PMID: 23209313)
Lancet. 2003 Jul 5;362(9377):30-7. (PMID: 12853196)
Gastroenterology. 1998 Sep;115(3):551-63. (PMID: 9721152)
Scand J Gastroenterol. 2006 Apr;41(4):408-19. (PMID: 16635908)
Gut. 2005 Sep;54(9):1217-23. (PMID: 16099789)
Aliment Pharmacol Ther. 2009 Jun 15;29(12):1299-308. (PMID: 19302264)
Springer Semin Immunopathol. 2005 Sep;27(2):217-32. (PMID: 16091925)
J Agric Food Chem. 2008 Feb 27;56(4):1387-91. (PMID: 18193828)
Autoimmun Rev. 2008 Sep;7(8):644-50. (PMID: 18589004)
Eur J Gastroenterol Hepatol. 1999 May;11(5):529-35. (PMID: 10755257)
Science. 2002 Sep 27;297(5590):2275-9. (PMID: 12351792)
Cell Mol Immunol. 2011 Mar;8(2):103-9. (PMID: 21278768)
Mol Nutr Food Res. 2011 Aug;55(8):1266-70. (PMID: 21710563)
J Immunol. 2004 Aug 1;173(3):1757-62. (PMID: 15265905)
J Exp Med. 2002 Mar 4;195(5):643-9. (PMID: 11877487)

0 (Prolamins)
8002-80-0 (Glutens)

Date Created: 20131025 Date Completed: 20140508 Latest Revision: 20211021

20250114

PMC3820067

10.3390/nu5104174

24152750