History of myeloid-derived suppressor cells.

Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124168 Publication Model: Print Cited Medium: Internet ISSN: 1474-1768 (Electronic) Linking ISSN: 1474175X NLM ISO Abbreviation: Nat Rev Cancer Subsets: MEDLINE

Original Publication: London, UK : Nature Pub. Group, [c2001-

Cell Biology/*history ; Medical Oncology/*history ; Multipotent Stem Cells/*cytology ; Myeloid Progenitor Cells/*cytology ; Neoplasms/*pathology; Animals ; Antigens, Differentiation/analysis ; Antigens, Neoplasm/analysis ; Cell Differentiation ; Cell Lineage ; Chemokines/physiology ; Hematopoiesis, Extramedullary ; Hematopoietic Stem Cell Mobilization/adverse effects ; History, 20th Century ; History, 21st Century ; Humans ; Leukemoid Reaction/pathology ; Mice ; Molecular Targeted Therapy ; Multipotent Stem Cells/drug effects ; Multipotent Stem Cells/physiology ; Myeloid Cells/cytology ; Myeloid Cells/drug effects ; Myeloid Cells/physiology ; Myeloid Progenitor Cells/drug effects ; Myeloid Progenitor Cells/physiology ; Neoplasm Invasiveness/physiopathology ; Neoplasm Metastasis ; Neoplasms/immunology ; Neovascularization, Pathologic/physiopathology ; Tumor Burden ; Tumor Escape ; Tumor Microenvironment

Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and escape from immunity via T cell suppression. Initially, these myeloid cells were identified as granulocytes or monocytes; however, recent studies have revealed that this hyperplasia is associated with populations of multipotent progenitor cells that have been identified as myeloid-derived suppressor cells (MDSCs). The study of MDSCs has provided a wealth of information regarding tumour pathobiology, has extended our understanding of neoplastic progression and has modified our approaches to immune adjuvant therapy. In this Timeline article, we discuss the history of MDSCs, their influence on tumour progression and metastasis, and the crosstalk between tumour cells, MDSCs and the host macroenvironment.

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R01 CA084488 United States CA NCI NIH HHS; R01 CA100062 United States CA NCI NIH HHS

0 (Antigens, Differentiation)
0 (Antigens, Neoplasm)
0 (Chemokines)

Date Created: 20130925 Date Completed: 20131211 Latest Revision: 20220318

20240829

PMC4358792

10.1038/nrc3581

24060865