A six-month randomized controlled trial of whole soy and isoflavones daidzein on body composition in equol-producing postmenopausal women with prehypertension.

Publisher: Wiley Country of Publication: United States NLM ID: 101526295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-0716 (Electronic) Linking ISSN: 20900708 NLM ISO Abbreviation: J Obes Subsets: MEDLINE

Publication: 2024- : [Hoboken, NJ] : Wiley
Original Publication: New York ; Cairo, Egypt : Hindawi Publishing Corporation, 2010-

Soy Foods*; Body Composition/*drug effects ; Equol/*blood ; Isoflavones/*therapeutic use ; Overweight/*therapy ; Phytoestrogens/*therapeutic use ; Postmenopause/*metabolism ; Prehypertension/*therapy; Adiposity/drug effects ; Aged ; Analysis of Variance ; Body Mass Index ; Body Weight/drug effects ; Double-Blind Method ; Female ; Hong Kong ; Humans ; Isoflavones/blood ; Isoflavones/urine ; Middle Aged ; Overweight/diagnosis ; Overweight/metabolism ; Overweight/physiopathology ; Phytoestrogens/blood ; Phytoestrogens/urine ; Predictive Value of Tests ; Prehypertension/diagnosis ; Prehypertension/metabolism ; Prehypertension/physiopathology ; Time Factors ; Treatment Outcome ; Waist Circumference ; Waist-Hip Ratio

Objectives: This paper reported the effects of commonly used whole soy foods (soy flour) and purified daidzein (one of the major isoflavones and the precursor of equol) on changes in anthropometric measurements and body composition in a 6-month double-blind, randomized, placebo-controlled trial among prehypertensive postmenopausal women who are also equol producers.
Methods: 270 eligible women were randomized to either one of the three treatments: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group), or 40 g low-fat milk powder (placebo group) daily each for 6 months. Anthropometric indicators and body composition were measured before and after intervention.
Results: 253 subjects completed the study with good compliance. Urinary isoflavones levels suggested good compliance of subjects with supplementation. Whole soy and purified daidzein had no significant effect on body weight, body mass index (BMI), waist and hip circumferences, waist to hip ratio (WHR), body fat percentage, fat mass, and free fat mass.
Conclusion: Six-month consumption of whole soy and purified daidzein at provided dosage had no improvement on body weight and composition compared with isocaloric milk placebo among prehypertensive equol-producing postmenopausal women. This trial is registered with ClinicalTrials.gov NCT01270737.

Int J Obes (Lond). 2010 Feb;34(2):309-18. (PMID: 19918248)
Metabolism. 1998 Nov;47(11):1308-14. (PMID: 9826205)
Endocrinology. 2003 Aug;144(8):3315-20. (PMID: 12865308)
Int J Med Sci. 2007 Feb 26;4(2):72-82. (PMID: 17396158)
Physiol Rev. 2000 Apr;80(2):649-80. (PMID: 10747204)
Metabolism. 2007 Feb;56(2):280-8. (PMID: 17224344)
Obes Rev. 2001 Aug;2(3):141-7. (PMID: 12120099)
J Am Diet Assoc. 2001 Dec;101(12):1416-9. (PMID: 11762736)
Maturitas. 2005 Oct 16;52(2):102-10. (PMID: 16186072)
Eur J Clin Nutr. 1999 Dec;53(12):959-65. (PMID: 10602354)
Nutrition. 2000 May;16(5):349-54. (PMID: 10793303)
Nutrition. 2007 Jul-Aug;23(7-8):551-6. (PMID: 17574819)
Menopause. 2007 Sep-Oct;14(5):866-74. (PMID: 17464237)
Maturitas. 2007 Apr 20;56(4):350-8. (PMID: 17084566)
Maturitas. 2005 Jul 16;51(3):299-306. (PMID: 15978974)
Eur J Clin Nutr. 2003 Apr;57(4):514-22. (PMID: 12700612)
Clin Exp Pharmacol Physiol. 2004 Dec;31 Suppl 2:S2-4. (PMID: 15649277)
J Nutr. 2006 Aug;136(8):2188-93. (PMID: 16857839)
Am J Obstet Gynecol. 2010 Aug;203(2):153.e1-9. (PMID: 20435291)
J Nutr. 2002 Dec;132(12):3577-84. (PMID: 12468591)
Nutrients. 2010 Aug;2(8):855-88. (PMID: 22254060)
Am J Clin Nutr. 1985 Apr;41(4):810-7. (PMID: 3984933)
Bioorg Med Chem. 2004 Mar 15;12(6):1559-67. (PMID: 15018930)
Am J Clin Nutr. 1996 Sep;64(3 Suppl):436S-448S. (PMID: 8780360)
Fertil Steril. 2007 Dec;88(6):1609-17. (PMID: 17412329)
Int J Obes (Lond). 2008 Sep;32(9):1431-7. (PMID: 18607383)
Climacteric. 2000 Dec;3(4):254-61. (PMID: 11910585)
Am J Clin Nutr. 1998 Dec;68(6 Suppl):1474S-1479S. (PMID: 9848519)
J Am Diet Assoc. 2007 Mar;107(3):500-5. (PMID: 17324670)
J Am Coll Nutr. 1992 Apr;11(2):199-209. (PMID: 1578098)
Br J Nutr. 2011 Apr;105(8):1199-209. (PMID: 21205384)
Am J Clin Nutr. 2005 Jan;81(1):189-95. (PMID: 15640479)
Curr Pharm Des. 2006;12(13):1637-43. (PMID: 16729875)
Menopause. 2003 Sep-Oct;10(5):427-32. (PMID: 14501604)
Ann Nutr Metab. 2008;52 Suppl 1:2-5. (PMID: 18382069)
J Endocrinol Invest. 2006;29(3 Suppl):77-82. (PMID: 16751711)
Plant Foods Hum Nutr. 2008 Mar;63(1):41-6. (PMID: 18157697)
Am J Clin Nutr. 2008 Jul;88(1):38-50. (PMID: 18614722)
Circ J. 2011;75(9):2235-43. (PMID: 21768737)
Asia Pac J Clin Nutr. 2011;20(3):383-9. (PMID: 21859656)
Baillieres Clin Endocrinol Metab. 1998 Dec;12(4):589-604. (PMID: 10384815)
Arch Intern Med. 2007 May 28;167(10):1060-7. (PMID: 17533209)
J Endocrinol Invest. 2003 Sep;26(9):893-901. (PMID: 14964443)
Eur J Clin Nutr. 1994 Apr;48(4):228-40. (PMID: 8039483)
J Altern Complement Med. 2005 Oct;11(5):909-15. (PMID: 16296926)
Menopause. 2003 Jul-Aug;10(4):322-31. (PMID: 12851515)
Am J Clin Nutr. 1998 Jun;67(6):1197-204. (PMID: 9625093)
Diabetes. 2008 May;57(5):1176-85. (PMID: 18420492)
J Nutr. 2011 Aug;141(8):1489-94. (PMID: 21677076)

ClinicalTrials.gov NCT01270737

0 (Isoflavones)
0 (Phytoestrogens)
531-95-3 (Equol)
6287WC5J2L (daidzein)

Date Created: 20130829 Date Completed: 20131223 Latest Revision: 20220311

20250114

PMC3747417

10.1155/2013/359763

23984051