Sequence-controlled polymers.

Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-

Polymerization*; Biopolymers/*chemistry; Catalysis ; DNA-Directed DNA Polymerase/chemistry ; Directed Molecular Evolution/methods ; Nucleic Acids/biosynthesis ; Nucleic Acids/chemical synthesis ; Nucleic Acids/chemistry ; Polymers/chemical synthesis ; Polymers/chemistry ; Templates, Genetic

Sequence-controlled polymers are macromolecules in which monomer units of different chemical nature are arranged in an ordered fashion. The most prominent examples are biological and have been studied and used primarily by molecular biologists and biochemists. However, recent progress in protein- and DNA-based nanotechnologies has shown the relevance of sequence-controlled polymers to nonbiological applications, including data storage, nanoelectronics, and catalysis. In addition, synthetic polymer chemistry has provided interesting routes for preparing nonnatural sequence-controlled polymers. Although these synthetic macromolecules do not yet compare in functional scope with their natural counterparts, they open up opportunities for controlling the structure, self-assembly, and macroscopic properties of polymer materials.

R01GM065865 United States GM NIGMS NIH HHS; United States Howard Hughes Medical Institute

0 (Biopolymers)
0 (Nucleic Acids)
0 (Polymers)
EC 2.7.7.7 (DNA-Directed DNA Polymerase)

Date Created: 20130810 Date Completed: 20130815 Latest Revision: 20130809

20231215

10.1126/science.1238149

23929982