Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Design for a lithographically patterned bioartificial endocrine pancreas.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Park J;Park J; Kalinin YV; Kadam S; Randall CL; Gracias DH
  • المصدر:
    Artificial organs [Artif Organs] 2013 Dec; Vol. 37 (12), pp. 1059-67. Date of Electronic Publication: 2013 Jul 22.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7802778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1594 (Electronic) Linking ISSN: 0160564X NLM ISO Abbreviation: Artif Organs Subsets: MEDLINE
    • بيانات النشر:
      Publication: Cambridge, MA : Wiley-Blackwell
      Original Publication: Cleveland, International Society for Artificial Organs.
    • الموضوع:
      Bioartificial Organs* ; Nanostructures* ; Tissue Scaffolds*; Insulin-Secreting Cells/*physiology ; Islets of Langerhans/*physiology ; Tissue Engineering/*methods; Animals ; Cell Hypoxia ; Cell Line, Tumor ; Computer-Aided Design ; Equipment Design ; Glucose/metabolism ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/cytology ; Islets of Langerhans/metabolism ; Mice ; Oxygen/metabolism ; Porosity ; Surface Properties ; Time Factors
    • نبذة مختصرة :
      Cell encapsulation provides a means to transplant therapeutic cells for a variety of diseases including diabetes. However, due to the large numbers of cells, approximately on the order of a billion, that need to be transplanted for human diabetes therapy, adequate mass transport of nutrients such as oxygen presents a major challenge. Proof-of-concept for the design of a bioartificial endocrine pancreas (BAEP) that is optimized to minimize hypoxia in a scalable and precise architecture is demonstrated using a combination of simulations and experiments. The BAEP is composed of an array of porous, lithographically patterned polyhedral capsules arrayed on a rolled-up alginate sheet. All the important structural variables such as the capsule dimensions, pore characteristics, and spacing can be precisely engineered and tuned. Further, all cells are encapsulated within a single device with a volume not much greater than the total volume of the encapsulated cells, and no cell within the device is located more than 200 μm from the surrounding medium that facilitates efficient mass transport with the surroundings. Compared with gel-based encapsulation methods, our approach offers unprecedented precision and tunability of structural parameters as well as the volume of the encapsulated cells and consequently the amount of secreted insulin. Our work highlights the utility of lithography and self-assembly in the fabrication of micro- and nanostructured three-dimensional structures that simulate the function of natural endocrine organs.
      (© 2013 Wiley Periodicals, Inc. and International Center for Artificial Organs and Transplantation.)
    • Contributed Indexing:
      Keywords: BioMEMS; Bioartificial pancreas; Cell encapsulation therapy; Diabetes; Insulin; Nanotechnology
    • الرقم المعرف:
      0 (Insulin)
      IY9XDZ35W2 (Glucose)
      S88TT14065 (Oxygen)
    • الموضوع:
      Date Created: 20130724 Date Completed: 20140728 Latest Revision: 20131216
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1111/aor.12131
    • الرقم المعرف:
      23876103