[Surface proteins of bacteria of the genus Bifidobacterium].

Białka powierzchniowe bakterii z rodzaju Bifidobacterium.

Publisher: Medical Science International Country of Publication: Poland NLM ID: 101206517 Publication Model: Electronic Cited Medium: Internet ISSN: 1732-2693 (Electronic) Linking ISSN: 00325449 NLM ISO Abbreviation: Postepy Hig Med Dosw (Online) Subsets: MEDLINE

Original Publication: [Warsaw, Poland] : Medical Science International, [2004]-

Bifidobacterium/*metabolism ; Intestinal Mucosa/*microbiology ; Membrane Proteins/*metabolism; Bifidobacterium/classification ; Bifidobacterium/growth & development ; Diarrhea/microbiology ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/microbiology ; Immunization ; Infant ; Intestinal Mucosa/immunology ; Irritable Bowel Syndrome/microbiology ; Irritable Bowel Syndrome/prevention & control ; Lactobacillus/growth & development ; Lactobacillus/metabolism ; Lactose Intolerance/microbiology ; Lactose Intolerance/prevention & control ; Species Specificity

Beneficial effects due to the presence of probiotic bacteria of the genus Bifidobacterium in the human intestinal tract are still an interesting object of study. So far activities have been confirmed of bifidobacteria in stimulation of the host immune system, stimulation of tumor cell apoptosis, improvement of bowel motility, alleviation of symptoms of lactose intolerance, cholesterol lowering capacity, prevention and treatment of diarrhea and irritable bowel syndrome, alleviation of allergy or atopic dermatitis, maintenance of homeostasis of the intestine, and stimulation of the development of normal intestinal microflora in infants. A multitude of therapeutic properties encourages researchers to investigate the possibility of using the potential of Bifidobacterium in the prevention and treatment of other conditions such as rheumatoid arthritis and depression. Although it is known that the beneficial effects are due to intestinal mucosal colonization by these bacteria, the cell components responsible for the colonization are still not determined. In addition to the beneficial effects of probiotic administration, there were also negative effects including sepsis. Therefore research has been directed to identify specific components of Bifidobacterium responsible for probiotic effects. Currently researchers are focused on identifying, isolating and evaluating the properties of surface proteins that are probably involved in the adhesion of bacterial cells to the intestinal epithelium, improving colonization. This paper is an overview of current knowledge on Bifidobacterium surface proteins. The ways of transport and anchoring proteins in Gram-positive bacterial cells, the assembly of cell wall, and a description of the genus Bifidobacterium are presented.

0 (Membrane Proteins)

Date Created: 20130613 Date Completed: 20130911 Latest Revision: 20181202

20240829

10.5604/17322693.1049285

23756375