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Effectiveness of egg yolk antibody against shiga toxin II variant toxicity in vitro and in vivo.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Feng Y;Feng Y; Liu W; Shi D
  • المصدر:
    Current microbiology [Curr Microbiol] 2013 Oct; Vol. 67 (4), pp. 448-53. Date of Electronic Publication: 2013 May 21.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0991 (Electronic) Linking ISSN: 03438651 NLM ISO Abbreviation: Curr Microbiol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: New York, Springer International.
    • الموضوع:
      Antibodies/*immunology ; Antibodies, Bacterial/*immunology ; Egg Yolk/*chemistry ; Shiga Toxin 2/*immunology ; Shiga Toxin 2/*toxicity ; Shiga-Toxigenic Escherichia coli/*immunology; Animals ; Chick Embryo ; Chickens ; Chlorocebus aethiops ; Egg Yolk/immunology ; Female ; Mice ; Neutralization Tests ; Shiga-Toxigenic Escherichia coli/physiology ; Vero Cells
    • نبذة مختصرة :
      We prepared anti-Shiga toxin II variant (Stx2e) and anti-Stx2e B antibodies in chicken egg yolk and investigated their effectiveness in vitro and in vivo. Both Egg yolk antibodies (IgY) reduced the cytotoxic effects of Stx2e to Vero cells. The protective efficacy of anti-Stx2e IgY and anti-Stx2e B IgY was investigated in clean Kunming mice, which were experimentally induced with Stx2e. Peritoneal injection of anti-Stx2e IgY and anti-Stx2e B IgY apparently reduced the lethal effect of Stx2e to mice. These results indicate that both anti-Stx2e IgY and anti-Stx2e B IgY could protect mice from Stx2e challenge. Therefore, anti-Stx2e IgY or anti-Stx2e B IgY might be considered as potential candidate for therapeutics for porcine edema disease.
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    • الرقم المعرف:
      0 (Antibodies)
      0 (Antibodies, Bacterial)
      0 (Shiga Toxin 2)
    • الموضوع:
      Date Created: 20130522 Date Completed: 20140224 Latest Revision: 20211021
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1007/s00284-013-0384-8
    • الرقم المعرف:
      23689941