Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Whole genome scanning and association mapping identified a significant association between growth and a SNP in the IFABP-a gene of the Asian seabass.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Xia JH;Xia JH; Lin G; He X; Liu P; Liu F; Sun F; Tu R; Yue GH
  • المصدر:
    BMC genomics [BMC Genomics] 2013 May 01; Vol. 14, pp. 295. Date of Electronic Publication: 2013 May 01.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, [2000-
    • الموضوع:
      Genome*; Bass/*genetics ; Bass/*growth & development ; Fatty Acid-Binding Proteins/*genetics; Animals ; Fasting/physiology ; Fatty Acid-Binding Proteins/biosynthesis ; Female ; Genetic Linkage ; Male ; Microsatellite Repeats ; Phenotype ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci
    • نبذة مختصرة :
      Background: Aquaculture is the quickest growing sector in agriculture. However, QTL for important traits have been only identified in a few aquaculture species. We conducted QTL mapping for growth traits in an Asian seabass F(2) family with 359 individuals using 123 microsatellites and 22 SNPs, and performed association mapping in four populations with 881 individuals.
      Results: Twelve and nine significant QTL, as well as 14 and 10 suggestive QTL were detected for growth traits at six and nine months post hatch, respectively. These QTL explained 0.9-12.0% of the phenotypic variance. For body weight, two QTL intervals at two stages were overlapped while the others were mapped onto different positions. The IFABP-a gene located in a significant QTL interval for growth on LG5 was cloned and characterized. A SNP in exon 3 of the gene was significantly associated with growth traits in different populations.
      Conclusions: The results of QTL mapping for growth traits suggest that growth at different stages was controlled by some common QTL and some different QTL. Positional candidate genes and association mapping suggest that the IFABP-a is a strong candidate gene for growth. Our data supply a basis for fine mapping QTL, marker-assisted selection and further detailed analysis of the functions of the IFABP-a gene in fish growth.
    • References:
      Anim Genet. 2008 Feb;39(1):34-9. (PMID: 18076743)
      BMC Genomics. 2010 Jun 04;11:356. (PMID: 20525308)
      Mol Syst Biol. 2011 Oct 11;7:539. (PMID: 21988835)
      Nat Genet. 2008 Jun;40(6):768-75. (PMID: 18454148)
      Mol Genet Genomics. 2007 Jun;277(6):647-61. (PMID: 17308931)
      Bioinformatics. 2007 Oct 1;23(19):2633-5. (PMID: 17586829)
      Science. 2002 Dec 20;298(5602):2345-9. (PMID: 12493905)
      Comp Biochem Physiol B Biochem Mol Biol. 2004 Aug;138(4):391-8. (PMID: 15325340)
      PLoS One. 2011 Jan 31;6(1):e16599. (PMID: 21304996)
      BMC Genet. 2010 Jul 07;11:63. (PMID: 20609225)
      Biochim Biophys Acta. 2000 Jan 31;1490(1-2):175-83. (PMID: 10786634)
      Anim Genet. 2009 Oct;40(5):753-5. (PMID: 19397515)
      Heredity (Edinb). 1999 Feb;82 ( Pt 2):134-41. (PMID: 10098263)
      Dev Dyn. 2004 Aug;230(4):734-42. (PMID: 15254907)
      Genet Sel Evol. 2010 Jun 04;42:17. (PMID: 20525320)
      Mol Ecol. 2005 Jul;14(8):2611-20. (PMID: 15969739)
      Nat Genet. 2001 Jul;28(3):286-9. (PMID: 11431702)
      DNA Res. 2011 Dec;18(6):513-22. (PMID: 22086997)
      Mol Genet Genomics. 2004 Sep;272(2):162-72. (PMID: 15449174)
      BMC Genomics. 2006 Oct 26;7:274. (PMID: 17064422)
      BMC Genet. 2008 Jan 29;9:12. (PMID: 18230136)
      Acta Biochim Biophys Sin (Shanghai). 2007 May;39(5):384-90. (PMID: 17492136)
      Anim Genet. 2012 Dec;43(6):753-9. (PMID: 22497460)
      Lipids. 2004 Jul;39(7):603-10. (PMID: 15588016)
      Genet Res (Camb). 2011 Oct;93(5):343-9. (PMID: 21878144)
      Heredity (Edinb). 2005 Feb;94(2):166-72. (PMID: 15483654)
      Nat Rev Genet. 2002 Jan;3(1):43-52. (PMID: 11823790)
      BMC Genet. 2011 Sep 21;12:81. (PMID: 21936917)
      Anim Genet. 2010 Aug;41(4):337-45. (PMID: 20028379)
      BMC Genomics. 2011 Apr 02;12:174. (PMID: 21457569)
      Mar Biotechnol (NY). 2011 Feb;13(1):74-82. (PMID: 20352272)
      Mol Biol Evol. 2007 Aug;24(8):1596-9. (PMID: 17488738)
      Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
      Int J Dev Biol. 2000 Feb;44(2):249-52. (PMID: 10794084)
      Genesis. 2004 Jan;38(1):26-31. (PMID: 14755801)
      Obesity (Silver Spring). 2008 Aug;16(8):1861-8. (PMID: 18551125)
      Science. 1994 Mar 25;263(5154):1771-4. (PMID: 8134840)
      Trends Genet. 2002 Oct;18(10):489-91. (PMID: 12350331)
      Hum Genet. 2011 Oct;130(4):539-46. (PMID: 21424381)
      J Exp Biol. 2007 Aug;210(Pt 16):2885-96. (PMID: 17690237)
      BMC Genomics. 2011 Sep 29;12:473. (PMID: 21958071)
      J Hered. 2002 Jan-Feb;93(1):77-8. (PMID: 12011185)
      Nat Rev Genet. 2002 Jan;3(1):22-32. (PMID: 11823788)
      Bioinform Biol Insights. 2009 Jun 04;3:29-35. (PMID: 20140063)
    • الرقم المعرف:
      0 (Fatty Acid-Binding Proteins)
    • الموضوع:
      Date Created: 20130503 Date Completed: 20131024 Latest Revision: 20240505
    • الموضوع:
      20240505
    • الرقم المعرف:
      PMC3653795
    • الرقم المعرف:
      10.1186/1471-2164-14-295
    • الرقم المعرف:
      23634810