Dual origin of melanocytes defined by Sox1 expression and their region-specific distribution in mammalian skin.

Publisher: Blackwell Publishing on behalf of the Japanese Society of Developmental Biologists Country of Publication: Japan NLM ID: 0356504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-169X (Electronic) Linking ISSN: 00121592 NLM ISO Abbreviation: Dev Growth Differ Subsets: MEDLINE

Publication: Tokyo : Blackwell Publishing on behalf of the Japanese Society of Developmental Biologists
Original Publication: Nagoya, Japanese Society of Developmental Biologists.

Melanocytes/*metabolism ; Neural Crest/*metabolism ; SOXB1 Transcription Factors/*metabolism ; Schwann Cells/*metabolism ; Skin/*metabolism; Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Cell Movement/genetics ; Cells, Cultured ; Epidermal Cells ; Epidermis/embryology ; Epidermis/metabolism ; Immunohistochemistry ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Melanocytes/cytology ; Mice ; Mice, Transgenic ; Microscopy, Fluorescence ; Neural Crest/cytology ; Neural Crest/embryology ; Neuroepithelial Cells/cytology ; Neuroepithelial Cells/metabolism ; SOXB1 Transcription Factors/genetics ; Schwann Cells/cytology ; Skin/cytology ; Skin/embryology

Melanocytes are pigment-producing cells generated from neural crest cells (NCCs) that delaminate from the dorsal neural tube. The widely accepted premise that NCCs migrating along the dorsolateral pathway are the main source of melanocytes in the skin was recently challenged by the finding that Schwann cell precursors are the major cellular source of melanocytes in the skin. Still, in a wide variety of vertebrate embryos, melanocytes are exclusively derived from NCCs. In this study, we show that a NCC population that is not derived from Sox1(+) dorsal neuroepithelial cells but are derived from Sox1(-) cells differentiate into a significant population of melanocytes in the skin of mice. Later, these Sox1(-) cells clearly segregate from cells that originated from Sox1(+) dorsal neuroepithelial cell-derived NCCs. The possible derivation of Sox1(-) cells from epidermal cells also strengthens their non-neuroepithelial origin.
(© 2013 The Authors Development, Growth & Differentiation © 2013 Japanese Society of Developmental Biologists.)

0 (Luminescent Proteins)
0 (SOXB1 Transcription Factors)
0 (Sox1 protein, mouse)

Date Created: 20130126 Date Completed: 20130725 Latest Revision: 20181202

20221213

10.1111/dgd.12034

23347447