Acute and potentially life-threatening tropical diseases in western travelers--a GeoSentinel multicenter study, 1996-2011.

Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE

Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene
Original Publication: Baltimore.

Communicable Diseases, Emerging/*epidemiology ; Travel/*statistics & numerical data ; Tropical Medicine/*statistics & numerical data; Acute Disease ; Adolescent ; Adult ; Africa, Western ; Aged ; Aged, 80 and over ; Asia, Southeastern ; Child ; Child, Preschool ; Cohort Studies ; Communicable Diseases, Emerging/diagnosis ; Databases, Factual ; Dengue/diagnosis ; Dengue/epidemiology ; Female ; Humans ; Infant ; Leptospirosis/diagnosis ; Leptospirosis/epidemiology ; Malaria, Falciparum/diagnosis ; Malaria, Falciparum/epidemiology ; Male ; Middle Aged ; Scrub Typhus/diagnosis ; Scrub Typhus/epidemiology ; Typhoid Fever/diagnosis ; Typhoid Fever/epidemiology ; Typhus, Endemic Flea-Borne/diagnosis ; Typhus, Endemic Flea-Borne/epidemiology ; Young Adult

We performed a descriptive analysis of acute and potentially life-threatening tropical diseases among 82,825 ill western travelers reported to GeoSentinel from June of 1996 to August of 2011. We identified 3,655 patients (4.4%) with a total of 3,666 diagnoses representing 13 diseases, including falciparum malaria (76.9%), enteric fever (18.1%), and leptospirosis (2.4%). Ninety-one percent of the patients had fever; the median time from travel to presentation was 16 days. Thirteen (0.4%) patients died: 10 with falciparum malaria, 2 with melioidosis, and 1 with severe dengue. Falciparum malaria was mainly acquired in West Africa, and enteric fever was largely contracted on the Indian subcontinent; leptospirosis, scrub typhus, and murine typhus were principally acquired in Southeast Asia. Western physicians seeing febrile and recently returned travelers from the tropics need to consider a wide profile of potentially life-threatening tropical illnesses, with a specific focus on the most likely diseases described in our large case series.

Am J Trop Med Hyg. 2005 Jan;72(1):21-5. (PMID: 15728861)
Arch Intern Med (Chic). 1946 Dec;78(6):629-61. (PMID: 20278487)
Lancet Infect Dis. 2005 Oct;5(10):623-8. (PMID: 16183516)
Euro Surveill. 2011 Jan 06;16(1):. (PMID: 21223835)
Clin Infect Dis. 2007 Jun 15;44(12):1560-8. (PMID: 17516399)
J Travel Med. 2012 Jan-Feb;19(1):44-53. (PMID: 22221811)
Emerg Infect Dis. 2006 Sep;12(9):1424-6. (PMID: 17073094)
Am J Public Health. 2010 Jul;100(7):1249-52. (PMID: 20466959)
Am J Trop Med Hyg. 2010 Jun;82(6):1121-6. (PMID: 20519611)
Emerg Infect Dis. 2009 Nov;15(11):1791-8. (PMID: 19891867)
BMJ. 2008 Jul 03;337:a120. (PMID: 18599471)
Scand J Infect Dis. 2010 Jul;42(6-7):445-9. (PMID: 20297927)
Trans R Soc Trop Med Hyg. 2006 Nov;100(11):1063-7. (PMID: 16714040)
Int J Antimicrob Agents. 2010 Nov;36 Suppl 1:S26-35. (PMID: 20705436)
N Engl J Med. 2001 May 17;344(20):1504-10. (PMID: 11357153)
JAMA. 2009 Aug 26;302(8):859-65. (PMID: 19706859)
J Clin Virol. 2010 Apr;47(4):303-5. (PMID: 20004144)
BMJ. 2012 Mar 27;344:e2116. (PMID: 22454091)
Emerg Infect Dis. 2009 Feb;15(2):185-91. (PMID: 19193261)
N Engl J Med. 2006 Jan 12;354(2):119-30. (PMID: 16407507)
Trans R Soc Trop Med Hyg. 2000 Apr;94 Suppl 1:S1-90. (PMID: 11103309)
J Travel Med. 2005 May-Jun;12(3):136-41. (PMID: 15996442)
Am J Trop Med Hyg. 2010 Mar;82(3):459-63. (PMID: 20207873)
Clin Infect Dis. 2004 Oct 15;39(8):1104-12. (PMID: 15486832)

G0701652 United Kingdom MRC_ Medical Research Council

Investigator: M Jensenius; PV Han; P Schlagenhauf; E Schwartz; P Parola; F Castelli; F von Sonnenburg; L Loutan; K Leder; DO Freedman; F Simon; J Delmont; G Carosi; F Chappuis; E Caumes; A Pérignon; GD Burchard; J Torresi; G Brown; K Kain; A Boggild; JS Keystone; P Pandey; R Pradhan; H Murphy; CM Coyle; M Wittner; P de Vries; MC Grobusch; K Gadroen; C Rapp; O Aoun; S Kanagawa; Y Kato; Y Mizunno; E Gkrania-Klotsas; A McCarthy; R Weber; R Steffen; S Hagmann; M Henry; AO Miller; DC Hale; R Anand; SS Gelman; PE Kozarsky; J Fairley; C Franco-Paredes; ED Barnett; MD Libman; B Ward; J Maclean; N Tachikawa; H Kurai; H Sagara; R López-Vélez; JA Pérez-Molina; LH Chen; ME Wilson; JD Cahill; G McKinley; C Licitra; A Crespo; P Doyle; W Ghesquiere; WM Stauffer; PF Walker; A Gurtman; F Basto; C Abreu; N Hynes; R Sack; R McKenzie; HH Askling; U Bronner; DG Lalloo; NJ Beeching; BA Connor; M Shaw; A Hern; N Haulman; D Roesel; EC Jong; V Field; PL Lim; A Wilder-Smith; W Piyaphanee; U Silachamroon; MW Lynch; S Tenenboim; S McLellan; M Mendelson; P Vincent; J Vincelette; P Holtom; J Goad; A Anglim; A Wang; J Eason; S MacDonald; TB Nutman; AD Klion; PT Phu; N Anderson; T Batchelor; D Meisch; R Muller; LM Valdez; H Siu; R Kass; C Perret; F Valdivieso; J Yates; V Ansdell; S Anderson

Date Created: 20130118 Date Completed: 20130401 Latest Revision: 20220129

20231215

PMC3583336

10.4269/ajtmh.12-0551

23324216