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NXCL-4950, a novel composite applicable to peripheral skin, is capable of increasing skin temperature by enhancing capillary circulation.

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  • المؤلفون: Kim DC;Kim DC; Lee CE
  • المصدر:
    Clinical and experimental dermatology [Clin Exp Dermatol] 2013 Apr; Vol. 38 (3), pp. 244-50. Date of Electronic Publication: 2012 Sep 25.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 7606847 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2230 (Electronic) Linking ISSN: 03076938 NLM ISO Abbreviation: Clin Exp Dermatol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2023- : Oxford : Oxford University Press
      Original Publication: Oxford : Blackwell Scientific Publications.
    • الموضوع:
      Complex Mixtures/*therapeutic use ; Peripheral Vascular Diseases/*drug therapy ; Plant Extracts/*therapeutic use ; Regional Blood Flow/*drug effects ; Skin Diseases/*drug therapy ; Skin Temperature/*drug effects ; Vasodilator Agents/*therapeutic use; Administration, Topical ; Adult ; Female ; Humans ; Laser-Doppler Flowmetry ; Male ; Microvessels/drug effects ; Scalp/drug effects ; Skin/blood supply ; Young Adult
    • نبذة مختصرة :
      Background: Rapid skin warming and prompt correct medical treatment lead to dramatic improvement in patients with peripheral capillary-related damage, such as injuries, Raynaud disease and frostbite.
      Aim: To characterize a novel composite, NXCL-4950, for use in a cosmetic lotion.
      Methods: The effects of NXCL-4950 on enhancing skin blood flow, skin temperature warming, and expansion of peripheral blood vessels and scalp microvessels were investigated.
      Results: Monitoring by laser Doppler perfusion imaging and thermal imaging showed that application of NXCL-4950 to the hands increased skin blood flow and temperature relative to the control (or placebo) group. For the 20 participants with a high Raynaud Condition Score, application of NXCL-4950 to the skin resulted in a mean increase of 215.53% in microvessel diameter and mean increase of 164.96% in the speed of blood flow. When NXCL-4950 was applied to the scalp, the microvessels around the hair roots were clearly visible after 20 min.
      Conclusion: NXCL-4950 is a potential candidate for enhancing peripheral skin temperature, and might be useful in the treatment of capillary-related disorders.
      (© The Author(s). CED © 2012 British Association of Dermatologists.)
    • الرقم المعرف:
      0 (Complex Mixtures)
      0 (NXCL-4950)
      0 (Plant Extracts)
      0 (Vasodilator Agents)
    • الموضوع:
      Date Created: 20120926 Date Completed: 20130917 Latest Revision: 20130322
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1111/j.1365-2230.2012.04371.x
    • الرقم المعرف:
      23006135