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DNA barcode identification of black cohosh herbal dietary supplements.

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  • المؤلفون: Baker DA;Baker DA; Stevenson DW; Little DP
  • المصدر:
    Journal of AOAC International [J AOAC Int] 2012 Jul-Aug; Vol. 95 (4), pp. 1023-34.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 9215446 Publication Model: Print Cited Medium: Print ISSN: 1060-3271 (Print) Linking ISSN: 10603271 NLM ISO Abbreviation: J AOAC Int Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2020- : Oxford : Oxford University Press
      Original Publication: Arlington, VA : AOAC International, c1992-
    • الموضوع:
      Electronic Data Processing*; Cimicifuga/*metabolism ; Dietary Supplements/*analysis ; Drug Contamination/*prevention & control ; Nonprescription Drugs/*analysis ; Plant Extracts/*analysis; Base Sequence ; Genetic Variation ; Humans ; Molecular Sequence Data ; Nonprescription Drugs/standards ; Nucleotides/chemistry ; Phytotherapy/adverse effects ; Polymerase Chain Reaction/methods ; Reproducibility of Results ; Sequence Analysis, DNA/methods ; Species Specificity
    • نبذة مختصرة :
      Black cohosh (Actaea racemosa) herbal dietary supplements are commonly consumed to treat menopausal symptoms, but there are reports of adverse events and toxicities associated with their use. Accidental misidentification and/or deliberate adulteration results in harvesting other related species that are then marketed as black cohosh. Some of these species are known to be toxic to humans. We have identified two matK nucleotides that consistently distinguish black cohosh from related species. Using these nucleotides, an assay was able to correctly identify all of the black cohosh samples in the validation set. None of the other Actaea species in the validation set were falsely identified as black cohosh. Of 36 dietary supplements sequenced, 27 (75%) had a sequence that exactly matched black cohosh. The remaining nine samples (25%) had a sequence identical to that of three Asian Actaea species (A. cimicifuga, A. dahurica, and A. simplex). Manufacturers should routinely test plant material using a reliable assay to ensure accurate labeling.
    • الرقم المعرف:
      0 (Nonprescription Drugs)
      0 (Nucleotides)
      0 (Plant Extracts)
    • الموضوع:
      Date Created: 20120914 Date Completed: 20121015 Latest Revision: 20191112
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.5740/jaoacint.11-261
    • الرقم المعرف:
      22970567