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Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices.
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- المؤلفون: Ioannides C;Ioannides C
- المصدر:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2013 Jan; Vol. 43 (1), pp. 15-28. Date of Electronic Publication: 2012 Jun 28.
- نوع النشر :
Journal Article; Review
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE
- بيانات النشر:
Publication: London : Informa Healthcare
Original Publication: London, Taylor & Francis.
- الموضوع:
- نبذة مختصرة :
1.Induction of the drug-metabolising enzyme systems is a major cause of clinically relevant drug interactions. The potential of a drug to engage in such interactions may be assessed in in vitro systems such as precision-cut tissue slices. 2.Precision-cut tissue slices have a number of important advantages compared with the use of cells in culture, especially when tissues with a heterogeneous cellular population are concerned. 3.Extensive studies concerned with the induction of cytochrome P450 and Phase II enzymes in precision-cut tissue slices from various animal and human tissues, such as liver, lung and intestine, using established inducing agents have revealed that slices mimic the in vivo situation. 4.Precision-cut tissue slices is a reliable, informative and cost-effective technique for assessing the potential of chemicals to up-regulate drug-metabolising enzyme systems.
- الرقم المعرف:
0 (Xenobiotics)
9035-51-2 (Cytochrome P-450 Enzyme System)
- الموضوع:
Date Created: 20120630 Date Completed: 20130523 Latest Revision: 20121203
- الموضوع:
20231215
- الرقم المعرف:
10.3109/00498254.2012.698766
- الرقم المعرف:
22742738
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