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Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices.

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  • المؤلفون: Ioannides C;Ioannides C
  • المصدر:
    Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2013 Jan; Vol. 43 (1), pp. 15-28. Date of Electronic Publication: 2012 Jun 28.
  • نوع النشر :
    Journal Article; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: London, Taylor & Francis.
    • الموضوع:
      Xenobiotics*/pharmacokinetics ; Xenobiotics*/pharmacology; Cytochrome P-450 Enzyme System/*biosynthesis ; Intestines/*enzymology ; Liver/*enzymology ; Lung/*enzymology ; Up-Regulation/*drug effects; Animals ; Enzyme Induction/drug effects ; Humans ; Microdissection ; Organ Culture Techniques/methods
    • نبذة مختصرة :
      1.Induction of the drug-metabolising enzyme systems is a major cause of clinically relevant drug interactions. The potential of a drug to engage in such interactions may be assessed in in vitro systems such as precision-cut tissue slices. 2.Precision-cut tissue slices have a number of important advantages compared with the use of cells in culture, especially when tissues with a heterogeneous cellular population are concerned. 3.Extensive studies concerned with the induction of cytochrome P450 and Phase II enzymes in precision-cut tissue slices from various animal and human tissues, such as liver, lung and intestine, using established inducing agents have revealed that slices mimic the in vivo situation. 4.Precision-cut tissue slices is a reliable, informative and cost-effective technique for assessing the potential of chemicals to up-regulate drug-metabolising enzyme systems.
    • الرقم المعرف:
      0 (Xenobiotics)
      9035-51-2 (Cytochrome P-450 Enzyme System)
    • الموضوع:
      Date Created: 20120630 Date Completed: 20130523 Latest Revision: 20121203
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.3109/00498254.2012.698766
    • الرقم المعرف:
      22742738