Differential expression of CXC chemokines CXCL10 and CXCL12 in term and pre-term neonates and their mothers.

Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 8912860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0897 (Electronic) Linking ISSN: 10467408 NLM ISO Abbreviation: Am J Reprod Immunol Subsets: MEDLINE

Publication: Copenhagen : Wiley-Blackwell
Original Publication: New York : Alan R. Liss, Inc., c1989-

Chemokine CXCL10/*metabolism ; Chemokine CXCL12/*metabolism ; Premature Birth/*immunology; Chemokine CXCL10/genetics ; Chemokine CXCL12/genetics ; Female ; Gene Expression Regulation ; Humans ; Infant, Newborn ; Pregnancy

Background and Aim: Pre-term delivery is a mostly unknown frequent disorder worldwide. This project aimed to investigate the circulating levels of CXCL12 (SDF-1) and CXCL10 (IP-10) in cord blood of term and pre-term delivered fetuses and their corresponding mothers.
Material and Methods: Cord and peripheral blood samples were collected from 50 pre-term and 50 term infants and their mothers. Serum levels of CXCL12 and CXCL10 were measured by ELISA.
Results: The findings of this study indicated that the circulating levels of CXCL10 were elevated in mothers bearing pre-term infants, while CXCL12 was only increased in pre-term infants.
Conclusion: The results suggested that the pathophysiological status of both mother and infant are involved in prematurity. Moreover, these findings suggest an inflammatory response in pre-term labor, which probably is controlled by inducible chemokines such as CXCL10.
(© 2012 John Wiley & Sons A/S.)

0 (Chemokine CXCL10)
0 (Chemokine CXCL12)

Date Created: 20120629 Date Completed: 20130205 Latest Revision: 20120912

20250114

10.1111/j.1600-0897.2012.01167.x

22738089