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Amino acid sensing mechanisms: an Achilles heel in cancer?

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Lamb RF;Lamb RF
  • المصدر:
    The FEBS journal [FEBS J] 2012 Aug; Vol. 279 (15), pp. 2624-31. Date of Electronic Publication: 2012 Jul 03.
  • نوع النشر :
    Journal Article; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Oxford, UK : Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies, c2005-
    • الموضوع:
      Amino Acids/*metabolism ; Neoplasms/*metabolism; Animals ; Bacteria/metabolism ; Fungi/metabolism ; Humans ; Lysosomes/metabolism ; Mechanistic Target of Rapamycin Complex 1 ; Multiprotein Complexes ; Neoplasms/pathology ; Proteins/metabolism ; Quorum Sensing ; Receptors, Amino Acid/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases
    • نبذة مختصرة :
      The act of increasing mass, either in non-dividing cells or in dividing cells seeking to provide new material for daughter cells, depends upon the continued presence of extracellular nutrients in order to conserve mass. For amino acid nutrients, it appears that their insufficiency for new protein synthesis is actively monitored by both prokaryotic and eukaryotic cells, eliciting appropriate cellular responses that may depend not only on bulk nutrient supply, but also on the abundance of specific amino acids.
      (© 2012 The Author Journal compilation © 2012 FEBS.)
    • الرقم المعرف:
      0 (Amino Acids)
      0 (Multiprotein Complexes)
      0 (Proteins)
      0 (Receptors, Amino Acid)
      EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
      EC 2.7.11.1 (TOR Serine-Threonine Kinases)
    • الموضوع:
      Date Created: 20120613 Date Completed: 20120926 Latest Revision: 20211203
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1111/j.1742-4658.2012.08659.x
    • الرقم المعرف:
      22686629