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Raalin, a transcript enriched in the honey bee brain, is a remnant of genomic rearrangement in Hymenoptera.

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اقرأ أكثر
  • المؤلفون: Tirosh Y;Tirosh Y; Morpurgo N; Cohen M; Linial M; Bloch G
  • المصدر:
    Insect molecular biology [Insect Mol Biol] 2012 Jun; Vol. 21 (3), pp. 305-18. Date of Electronic Publication: 2012 Mar 09.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Blackwell Scientific For The Royal Entomological Society Country of Publication: England NLM ID: 9303579 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2583 (Electronic) Linking ISSN: 09621075 NLM ISO Abbreviation: Insect Mol Biol Subsets: MEDLINE
    • بيانات النشر:
      Publication: Oxford : Blackwell Scientific For The Royal Entomological Society
      Original Publication: Oxford : Published for the Royal Entomological Society by Blackwell Scientific Publications, c1992-
    • الموضوع:
      Honey*; Bees/*genetics ; Brain/*metabolism ; Gene Rearrangement/*genetics ; Genome, Insect/*genetics ; Hymenoptera/*genetics ; RNA, Messenger/*genetics; Amino Acid Sequence ; Animals ; Base Sequence ; Bees/growth & development ; Computational Biology ; Cysteine/metabolism ; Drosophila ; Evolution, Molecular ; Gene Expression Regulation, Developmental ; Insect Proteins/chemistry ; Molecular Sequence Data ; Organ Specificity/genetics ; Peptides/chemistry ; Phylogeny ; RNA, Messenger/metabolism ; RNA, Untranslated/genetics ; Sequence Alignment ; Species Specificity ; Toxins, Biological/chemistry
    • نبذة مختصرة :
      We identified a predicted compact cysteine-rich sequence in the honey bee genome that we called 'Raalin'. Raalin transcripts are enriched in the brain of adult honey bee workers and drones, with only minimum expression in other tissues or in pre-adult stages. Open-reading frame (ORF) homologues of Raalin were identified in the transcriptomes of fruit flies, mosquitoes and moths. The Raalin-like gene from Drosophila melanogaster encodes for a short secreted protein that is maximally expressed in the adult brain with negligible expression in other tissues or pre-imaginal stages. Raalin-like sequences have also been found in the recently sequenced genomes of six ant species, but not in the jewel wasp Nasonia vitripennis. As in the honey bee, the Raalin-like sequences of ants do not have an ORF. A comparison of the genome region containing Raalin in the genomes of bees, ants and the wasp provides evolutionary support for an extensive genome rearrangement in this sequence. Our analyses identify a new family of ancient cysteine-rich short sequences in insects in which insertions and genome rearrangements may have disrupted this locus in the branch leading to the Hymenoptera. The regulated expression of this transcript suggests that it has a brain-specific function.
      (© 2012 The Authors. Insect Molecular Biology © 2012 The Royal Entomological Society.)
    • الرقم المعرف:
      0 (Insect Proteins)
      0 (Peptides)
      0 (RNA, Messenger)
      0 (RNA, Untranslated)
      0 (Toxins, Biological)
      K848JZ4886 (Cysteine)
    • الموضوع:
      Date Created: 20120313 Date Completed: 20121105 Latest Revision: 20131121
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1111/j.1365-2583.2012.01138.x
    • الرقم المعرف:
      22404450